Surviving woman cancer According to a new study, the longest ever reported case of COVID-19 was infected with the new coronavirus for almost a year.
A 47-year-old woman was first admitted to COVID-19 at the National Institutes of Health (NIH) in Maryland in the spring of 2020. Science magazine reported.. Her infection lasted 335 days and was followed by repeated positive COVID-19 tests and prolonged symptoms requiring oxygenation at home.
Her test was positive, virus Her body level was almost undetectable for several months after her initial infection. Then, in March 2021, her virus level soared again. Researchers have compared the genomes from samples collected during her initial infection with more recent ones and found that the viruses are the same. In other words, the patient did not re-infect, but remained carrying the same virus for almost a year, the authors reported in a study posted as a preprint. medRxiv, Has not been peer reviewed yet.
According to Science Magazine, the new coronavirus could stay in a woman’s body longer because her immune system was damaged by previous treatment for lymphoma, a cancer that is part of the immune system. The patient was successfully treated with CAR T cell therapy about three years ago, weakening the immune system by depleting most of the body’s B cells. Immune system Cells to make antibody..
There are sporadic reports of immunocompromised patients who have shed the virus for much longer than expected, such as leukemia patients in Washington. Shed the virus for 70 days, But this is the longest reported case.
Elodie Ghedin, senior research author and molecular virologist at NIH, told Science Magazine that infections in patients with weakened immune systems “give a window on how the virus explores the genetic space.” .. By analyzing samples from this patient and people with other chronic infections, researchers can see how the virus evolves.
In a coronavirus sampled from a patient with lymphoma, researchers found two gene deletions (mutations that erase part of the genome). One is in several genes that code for the viral spike protein (the arm that the virus uses to invade). Human cells) and other large deletions on the outside of peplomer-a region that is little known due to lack of research. Other researchers have found similar deletions in that region outside the peaplomer in patients with chronic infections, Science Magazine reported.
Chronic infections are rare, but the virus can lead to new variants because it has more time and space to evolve in a body with a weakened immune system. Lymphoma patients who have been hospitalized again and treated for COVID-19 infection have finally cleared the virus and have undergone multiple COVID-19 negative tests since April.
read Case study details In Science Magazine.
Originally published in Live Science.
Women infected with COVID-19 for 335 days — longest on record
Source link Women infected with COVID-19 for 335 days — longest on record
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