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    When it comes to dengue and Zika, dengue antibodies can knock out Zika—and vice versa

    Researchers processing samples collected from participants in a pediatric dengue cohort study in Managua, Nicaragua. Credit: Paolo Harris Paz

    Cross-protective antibodies from dengue and Zika last much longer than previously thought. Scientists have discovered in a large study of more than 4,000 children in Nicaragua.

    An 11-year longitudinal analysis predicts that antibodies from either dengue or Zika virus (which naturally protects against infection by either virus) have been stable for years and will not decline sharply. It became clear to.

    Solve scientific mysteries about old and new enemies such as dengue fever infection Like Zika fever, it helps to lay the scientific foundation for a better response to future outbreaks.

    With the sudden emergence of the Zika virus in 2015, the world has been vigilant. Medical world In multiple countries, we are working on an explosive number of babies born with microcephaly, namely the small size of the head and brain.Now, six years after the catastrophic pandemic, how Human immune system It reacts to dengue fever and its closely related viral cousin, Zika fever.

    The results of new longitudinal studies could ultimately change the way scientists understand dengue and innate immunity to the Zika virus, as well as future studies that include efforts to predict and control vaccine efficacy and outbreaks. May give information.

    Leah C, Department of Infectious Diseases and Vaccines, University of California, Berkeley. Dr. Katzelnick said: ..

    Dengue fever is endemic in Central America and elsewhere in the “Dengue tropics” and is a vast zone of the globe, including tropical and subtropical regions.Often called Dengue feverInfections can cause muscle and joint pain and, in severe cases, internal bleeding and shock. Anyone who is infected a second time is at risk of serious symptoms. In contrast, Zika fever had not been detected in the Western Hemisphere until its sudden appearance in 2015. Mosquito-borne viruses were not only at risk for pregnant women and their foets, but were particularly threatening.

    Katzelnick et al. Scientific translation medicine, So they emphasized that their findings could affect how scientists and physicians understand the two upcoming infectious diseases.

    “Previously, the first infection with dengue or Zika was considered. [viruses] Antibodies are initially defensive, but decline over time, enhancing and driving serious illness. ” Vulnerable to infection with other dengue serotypes.

    write in Scientific translation medicineWelcomed by Katzelnick and her collaborators from the Institute of Sustainable Sciences in Berkeley, University of Michigan, Managua Nika Lagua, their findings are a new understanding of human immune response to dengue and Zika virus, and both. I concluded that I would open the window.

    Antibodies Secrets: With respect to dengue and Zika, dengue antibodies can knock out Zika. The reverse is also true.

    A child scanning his finger as part of his participation in a pediatric dengue cohort study in Managua, Nicaragua. Credit: Alejandro Belli

    Protection of cross-reactive antibodies was fully demonstrated during the 2015 Zika epidemic that struck multiple countries in the Caribbean and Latin America. Surprisingly, the incidence of dengue decreased dramatically in the midst of a surge in Zika. Because dengue and Zika are members of the same flavivirus family, patients who recovered from dengue infection had cross-protective antibodies that could neutralize dengue and Zika. Both viruses are carried by Aedes aegypti.

    Nonetheless, previous studies suggested that cross-reactive antibodies lasted only two years before they actually dropped to levels that increased the likelihood of future dengue infections. Scientists in 2015, at least anecdotally, realized that, surprisingly, some people have immune defenses against the emerging Zika virus.

    Katzelnick et al. Designed a study that would allow us to track antibody responses to early and secondary dengue and Zika infections. The team focused on a cohort of children in hospitals rooted in the Nicaragua region. Surprisingly, antibody Kenetics studies have allowed scientists to conclude that cross-protective antibodies have been stable for 11 years.

    The model predicted that these antibodies would have a very long half-life in the community cohort, but it is important to note that the antibodies gradually declined in children with secondary dengue virus infection.

    This study investigated multiple dengue serotypes, defined in the analysis as serotypes 1, 2, 3, and 4. The first dengue virus infection is thought to induce a declined antibody in two years, reduce defense, and greatly reduce the likelihood of subsequent dengue disease. .. However, secondary dengue infections with different serotypes are thought to induce stable cross-serotype protective antibodies.

    To better understand antibody activity, scientists used the dengue-inhibiting enzyme-bound immunoadsorption assay (iELISA) to measure antibodies associated with protection against dengue and Zika fever.

    “Surprisingly, overall Dengue virus iELISA titer is stable by 8 months after the first generation Dengue fever Infection with a half-life longer than human life [then] It has declined. “

    According to the team’s research, the half-life longer than human life is estimated to be 130,000 years.

    The team also observed cross-defense antibodies that were similarly stable in children infected with Zika. virus..However, the amount of cross-protective antibody varies from child to child, which is antibody Determine the degree of protection.


    Scientists Discover How Dengue Vaccines Can’t Protect You From Disease


    For more information:
    Leah C. Katzelnick et al, dengue and Zika virus infections in children induce long-lasting cross-reactive defense and enhanced antibodies. Scientific translation medicine (2021). DOI: 10.1126 /scitranslmed.abg9478

    © 2021 Science X Network

    Quote: Antibodies Secrets: With respect to dengue and Zika, dengue antibodies can knock out Zika. The reverse is also true (November 19, 2021). November 19, 2021 Obtained from https://medicalxpress.com/news/2021-11-secrets-Antibody-Dengue-zika-zikaand.html

    This document is subject to copyright. No part may be reproduced without written permission, except for fair transactions for personal investigation or research purposes. Content is provided for informational purposes only.

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