Researchers at the University of Oxford today share their findings on people vaccinated with the highest risk of severe COVID-19 leading to hospitalization or death 14 days after the second vaccination, which is expected to have substantial immunity. I reported.
In a treatise published in British Medical Journal, They have a list of people who were advised to directly influence UK policy in February 2021 and shield 1.5 million people in February 2021 by updating the QCovid tool developed in 2020. By adding to, it is possible to identify groups at high risk of hospitalization. death From COVID-19.
They used a national linked dataset from General medical care, National immunization and SARS-CoV-2 tests, death registration and hospital episode data, 5.2 m of which are both vaccinated to analyze a sample of more than 6.9 million vaccinated adults , This was representative of the entire UK population. .. This sample included 2,031 COVID-19 deaths and 1,929 COVID-19-related hospitalizations, of which 81 deaths and 71 hospitalizations occurred more than 14 days after the second vaccination. ..
Based on this, the researchers developed a cumulative risk score to calculate the risk of people hospitalized or dying from COVID-19 after one or two vaccinations. These scores take into account factors such as age, gender, ethnicity, and background rate of COVID infection, and in particular highlight the following increased risk:
- People who are immunosuppressed as a result of chemotherapy, recent bone marrow or solid organ transplants, or HIV / AIDS
- People with neuropathy such as dementia and Parkinson’s disease
- Residents of long-term care facilities and people with chronic illnesses such as Down’s syndrome
Julia Hippisley Cox, a professor of clinical epidemiology and general practice at Oxford University, co-author of this treatise, said:
“The UK is the first place to implement a vaccination program and has some of the best clinical research data in the world. Using the QResearch database to develop this new tool, NHS targeted it. Despite intervention vaccination, we have made it possible to identify patients at highest risk of serious outcomes. This new tool discusses the level of risk that supports shared decision-making between doctors and patients. You can also provide information to.
Researchers report that the group receiving the second dose of the vaccine had relatively few COVID-19-related hospitalizations or deaths. That is, the above groups are more or less at risk after the second vaccination compared to after the first dose.
In addition, they do not distinguish between the types of vaccination provided, for example occupations are not often recorded in general practice or hospital records, so their studies may have been limited by factors such as exposure. I admitted that there is.
Aziz Sheikh, a professor of primary care research and development, director of the Usher Institute at the University of Edinburgh, and co-author of the paper, said:
This large national survey of more than 5 million people who received two doses across the UK found that a small number of people were at risk of hospitalization and death from COVID-19. Our risk calculator helps identify those who remain at the highest risk after vaccination.
“The new QCovid tool, developed with the help of experts across the UK, will identify people at high risk who may benefit from interventions such as vaccine booster doses and new therapies such as monoclonal antibodies. Designed. Impact of progressive SARS-CoV-2 infection on severe COVID-19 outcomes.
Researchers use these data in a variety of health and care settings to notify people at high risk and identify them for further testing of vaccines, boosters, or future preventative therapies. I hope it can help to prioritize those who have been vaccinated.
Professor Hippisley-Cox concludes:
“Individual risk always depends on individual choices and current disease prevalence, but we hope this new tool will help with decision sharing and more personalized risk assessment.”
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