Wednesday, January 19, 2022

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    T cells from common colds cross-protect against infection with SARS-CoV-2

    Colored scanning electron micrograph of SARS-CoV-2 virus. Credit: NIAID

    New research published in Nature Communications Leading by researchers at Imperial College London, we provide the first evidence of the protective role of these T cells. Previous studies have shown that T cells induced by other coronaviruses can recognize SARS-CoV-2, but new studies show the presence of these T cells upon exposure to SARS-CoV-2. Find out for the first time how it affects if someone gets infected. ..

    Researchers also say their findings provide a second-generation blueprint, Universal flu vaccine It can be prevented infection From current and future SARS-CoV-2 variants, including Omicron.

    Dr. Leah Kundu, lead author of research at the Imperial National Institute of Cardiopulmonary Research, said:High level existing T cellCreated by the body when infected with other human coronaviruses, such as the common cold, can be protected from COVID-19 infection.

    “This is an important discovery, but it’s just one form of protection. It’s important to emphasize that you shouldn’t rely on this alone. Instead, the best way to protect yourself from COVID-19 is Complete vaccination. Booster effect. “

    The study began in September 2020, when most people in the United Kingdom were neither infected nor vaccinated with SARS-CoV-2. This included 52 people who were exposed to the virus because they lived with SARS-CoV-2 infected individuals confirmed by PCR. Participants performed PCR tests at the beginning, after 4 days, and after 7 days to determine if they had developed the infection.

    Blood samples from 52 participants were taken within 1-6 days of exposure to the virus. This allowed researchers to analyze pre-existing T cell levels induced by common cold coronavirus infections prior to mutual recognition of SARS-CoV-2 virus proteins.

    The researchers found that the levels of these cross-reactive T cells were significantly higher in the 26 uninfected individuals compared to the 26 infected.These T cells targeted internal proteins within the SARS-CoV-2 virus rather than spikes. protein On the surface of the virus, to protect it from infection.

    The current vaccine is Immune response To these internal proteins. In addition to existing effective peplomer-targeted vaccines, researchers have found that these internal proteins provide long-term protection because T-cell responses last longer than antibody responses that diminish within months of vaccination. It states that it will provide new vaccine targets that can provide.

    Professor Ajit Lalvani, senior author of the study and director of the Imperial NIHR Respiratory Infectious Diseases Health Protection Research Unit, said: -2 infection.These T cells provide protection by attacking proteins within virus, Not the peplomer on its surface.

    “Peplomer is subject to strong immune pressure from vaccine-induced antibodies, vaccination Escape the mutant. In contrast, the internal proteins targeted by the protected T cells we have identified are much less mutated. As a result, they are highly conserved among the various SARS-CoV-2 variants, including Omicron. Therefore, new vaccines containing these conserved internal proteins induce a broadly protective T cell response that should protect against current and future SARS-CoV-2 mutants. “

    Researchers have noted some limitations to the study, including the inability to model demographic factors because the study was small and 88% of the participants were Caucasian of European descent.

    New target for the identified COVID-19 vaccine

    Quote: Common cold T cells cross-defend against SARS-CoV-2 (2022, January 10) infection, https: // Obtained from -colds-cross-January 10, 2022 Protection-Infection.html

    This document is subject to copyright. No part may be reproduced without written permission, except for fair transactions for personal investigation or research purposes. Content is provided for informational purposes only.

    T cells from common colds cross-protect against infection with SARS-CoV-2 Source link T cells from common colds cross-protect against infection with SARS-CoV-2

    The post T cells from common colds cross-protect against infection with SARS-CoV-2 appeared first on California News Times.

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