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    Study uncovers a new understanding of how mesenchymal stromal cells benefit patients in cell therapy

    Apoptotic MSCs (red) are swallowed by macrophages (green).Credit: Professor Tracy Heng

    The therapeutic benefit to patients receiving mesenchymal cell (MSC) therapy is not because the injected cells remain alive, but because of cell death, a study by the Monash Biomedicine Discovery Institute (BDI). Discovered.

    In recent years, great efforts have been made to develop stem cell-based therapies for difficult-to-treat diseases. MSC Treatment Is a regenerative cell-based therapy for the treatment of these diseases and holds great promise.

    The results of the BDI study Therapeutic effect The proportion of MSCs is due to the immunity of the recipient cell Corresponds to a particular type of MSC Cell death, Called post-injection apoptosis, which has an anti-inflammatory effect.

    Apoptosis is more than just cell death. This is a regulated process that ensures that dying cells do not activate unwanted inflammation and instead promote an anti-inflammatory environment.

    These apoptotic cells produce extracellular factors with anti-inflammatory or therapeutic effects that may be available as alternatives to cell-based therapies.

    In this study, led by Associate Professor Tracy Heng, nullifying MSC apoptosis disables cells in alleviating the disease for which MSC is currently being tested as a treatment in models of pneumonia and multiple sclerosis. I found out.

    Survey results are currently available Nature Communications..

    Associate Professor Heng said that the choice of MSC batch for clinical use in the production of therapeutic cells has so far relied on laboratory evaluations to measure the secretion of bioactive factors or the expression of specific cell markers by viable MSCs. It says that it was.

    “By better understanding how Immune cells In response to the dying MSC, it may be possible to develop new therapeutic strategies that directly target the corresponding immune cell population and deliver anti-inflammatory effects. “

    Cell therapy with MSC has shown promising results in multiple diseases, from inflammatory conditions to autoimmunity and organ transplantation. MSCs are thought to secrete many soluble factors that contribute to therapeutic efficacy. However, this mechanism of action is inconsistent with the finding that infused MSCs do not persist in the body.

    “Knowing how MSC therapy works is important in designing treatment protocols that improve disease outcomes,” said Heng.


    New stem cell therapy approaches have proven effective in treating COVID-19


    For more information:
    Apoptosis of mesenchymal stromal cells is required for their therapeutic function. Nature Communications (2021). DOI: 10.1038 / s41467-021-26834-3

    Provided by
    Monash University

    Quote: The study reveals a new understanding of how mesenchymal stromal cells can help patients in cell therapy (November 11, 2021). .html

    This document is subject to copyright. No part may be reproduced without written permission, except for fair transactions for personal investigation or research purposes. The content is provided for informational purposes only.

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    The post Study uncovers a new understanding of how mesenchymal stromal cells benefit patients in cell therapy appeared first on California News Times.

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