According to a new treatise published this week, a set of seven symptoms can be considered together and used to maximize the detection of COVID-19 in the community. PLOS medicine By Marc Chadeau-Hyam and Paul Elliott of Imperial College London, England, and colleagues.
Rapid detection of SARS-CoV-2 infection in the community is key to ensuring efficient control of infection. If your test capacity is limited, it is important to use your tests in the most efficient way possible, such as using the symptoms that are most beneficial to your test allocation. In a new study, researchers obtained throat and nasal swabs with valid SARS-CoV-2 PCR test results from 1,147,345 volunteers in the United Kingdom over the age of five. Data were collected over eight test rounds conducted between June 2020 and January 2021 as part of the Real-Time Assessment of Community Communication-1 (REACT-1) study. Participants were asked about the symptoms they experienced the week before the test.
The model was developed based on the data obtained between rounds 2 and 7 and seven symptoms were selected as jointly positive predictors of PCR positive: loss of odor or change, loss of taste. Or changes, fever, new persistent cough, chills, loss of appetite, and muscle aches. The first four of these symptoms are currently being used in the United Kingdom to determine the eligibility of community PCR tests. In the eighth round of the test, the resulting model predicted PCR positives in the area below the curve of 0.77, and tested people in the community with at least one of the seven selected positive predictive symptoms, sensitivity, specificity, and A positive predictive value of 74% was obtained. , 64%, and 9.7%.In modeling, using the seven symptoms identified in the PCR test assignment, 30% to 40% of symptomatic individuals in the United Kingdom test And if all of the eligible ones are tested (against the current 10%), 70% to 75% of positive cases will be detected.
“We propose to extend the list of symptoms used for triage to all seven identified symptoms in order to improve the detection rate of PCR positives and, as a result, the control of viral infections by quarantine means. “The author states.
“These findings suggest that many people with COVID-19 are not tested and therefore do not self-isolate, because their symptoms help identify infected people today. It doesn’t match the symptoms used in public health guidance, “Elliott adds. .. “We understand that clear testing standards are needed and that people are at risk of unnecessarily self-isolating, including many of the symptoms commonly found in other illnesses such as seasonal flu. Our findings on beneficial symptoms help the test program leverage the available evidence to optimize the detection of infected individuals. ”
Elliott J, Whitaker M, Bodienia B, Eels O, Riley S, Ward H, et al. (2021) Predictive symptoms of COVID-19 in the community: REACT-1 study of more than 1 million people. PLoS Med 18 (9): e1003777. doi.org/10.1371/journal.pmed.1003777
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Quote: Https: //medicalxpress.com/news/2021-09-symptoms-jointly-covid-diagnosis.html jointly with COVID-19 diagnosis (September 28, 2021) obtained on September 28, 2021 7 Predictive Symptoms
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