Research reveals drug targets for memory enhancement


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Bristol-led research has identified specific drug discovery targets within neural circuits that encode memory, paving the way for significant advances in the treatment of a wide range of brain disorders.

Memory loss is a central feature of many neurological and psychiatric disorders, including Alzheimer’s disease and schizophrenia.Current treatment options amnesia Is very limited, and the search for safe and effective drug therapies has been of limited success so far.

The study was conducted in collaboration with colleagues at Sosei Heptares, an international biopharmacy company.Survey results published in Nature CommunicationsIdentify specific receptors for Neurotransmitter acetylcholine Rerouting the information flowing through the hippocampal memory circuit.Acetylcholine will be released at brain It is essential for acquiring new memories during learning. To date, the only effective treatment for the symptoms of cognitive or memory impairment found in diseases such as Alzheimer’s disease is the use of broadly boosted medications. acetylcholine..However, this leads to multiple Harmful side effects.. The discovery of specific receptor targets that may provide positive effects while avoiding negative effects is promising.

Professor Jack Meller, lead author of the University of Bristol Synaptic Plasticity Center, said: Receptor proteins In the long run, the discovery of these specific targets opens the way and opportunity to develop new treatments for Alzheimer’s disease symptoms and other conditions with marked cognitive impairment. Industry-academia collaboration is important for these discoveries. And we hope to continue working together on these projects. “

Dr. Miles Congreve, Chief Scientific Officer of Sosei Heptares, said: This approach has the exciting potential to improve memory and cognitive function in patients with Alzheimer’s disease and other neurological disorders. “

“It’s fascinating how the brain understands what is important to prioritize and encode different pieces of information. memory And what can be thrown away? We know that there must be a mechanism to elicit what is important to us, but we know very little about how these processes work. Our future research program aims to show how the brain does this using acetylcholine along with other neurotransmitters such as dopamine, serotonin, and noradrenaline. ” Professor Meller said.

How medicines can help your brain code memory

For more information:
Acetylcholine prioritizes synaptic inputs from the entorhinal cortex to CA1 by differential modulation of feedforward inhibitory circuits. Nature Communications (2021). DOI: 10.1038 / s41467-021-25280-5

Quote: According to the survey, the drug target of memory enhancement (September 16, 2021) obtained from https: // on September 16, 2021 Revealed

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