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Protecting the microbiome essential to fighting antibiotic-resistant bacteria

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Protecting microbiomes may be essential to control the spread of harmful and drug-resistant bacteria, a study published today suggests. eLife..

With trillions of bacteria inhabiting the human body, there is increasing evidence that this microbiome is essential for human health.Findings add to this evidence by showing that a healthy microbial flora not only plays an important role in preventing or fighting infection, but also helps reduce the spread of drug-resistant strains. Harmful bacteria..

Antibiotics are an important tool for treating infections caused by harmful bacteria, but they can also harm the microbiome. Without a healthy microbial flora, there is less competition for resources where harmful bacteria can grow.

“Usage Antibiotics It can also result in the emergence of strains of both useful and harmful bacteria. Genetic mutation David Smith, the lead author and a doctoral student at the Pasteur Institute and the CESP Institute in France (French National Institute of Health Sciences / University of Versailles Saint Quentin en Eveline (USVQ)), explained: I am. Mathematical modeling was used to determine how the effects of antibiotics on the microbiome promote the spread of antibiotic-resistant strains in the medical setting. “

By modeling how harmful it is Antibiotic resistant bacteria Smith and his colleagues interact with the microbiome and show how the use of antibiotics alters those interactions. Use of antibiotics It plays a huge role in increasing the abundance of drug-resistant pathogens. This is done by clearing out useful microbial communities that prevent harmful bacteria from colonizing.

“It shows the trade-off that antibiotics simultaneously remove harmful bacteria and make them more susceptible to the same bacteria,” said Professor Laura Temier, co-chief author of the National Conservatory of Arts in France.

The team then simulated how well various preventive strategies work to stop the spread of drug-resistant bacteria such as Clostridium difficile, methicillin-resistant Staphylococcus aureus, and multidrug-resistant gut microbiota. bottom. Their results show that preventative measures to prevent infection by harmful bacteria, such as Enterobacteriaceae, may have limited benefits. However, interventions that protect the microbiome, such as reducing antibiotic use and helping patients recover their microbiota after antibiotic treatment, may Drug resistant bacteria..

“Our research reveals how important it is to consider the protective effects of a healthy microbial flora when designing strategies to reduce the spread of drug-resistant strains,” co-chief. The author, Lulla Opatowski, a professor of mathematical epidemiology at UVSQ, concludes. Epidemiology and modeling researcher in the Antibiotic Avoidance Group at the Pasteur Institute. “Together, both antibiotic management and interventions to support Healthy microbial flora It may be effective in reducing the burden of these infections. ”

Three important questions about antibiotic resistance

For more information:
David RM Smith et al, Microbiota-Pathogen Interaction Promotes Epidemiological Dynamics of Antibiotic Resistance: Modeling Studies Applied to In-Hospital Pathogen Control, eLife (2021). DOI: 10.7554 / eLife.68764

Journal information:

Quote: Protecting the microbiome essential for fighting antibiotic-resistant bacteria (September 14, 2021) https: // Obtained from September 14, 2021.

This document is subject to copyright. No part may be reproduced without written permission, except for fair transactions for personal investigation or research purposes. The content is provided for informational purposes only.

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