Prostate cancer molecular feature with prognostic value, distinguishes ancestral differences

Date:

Tissue microarray slides stained with ERV3 antibody. Tumor tissue samples from patients with BA ancestors are shown on the left and samples from patients with WA ancestors are shown on the right. A scatter plot of ERV 3-1 percent positive on tissue microarrays (TMA) from 52BA and 90WA patient samples is also shown on the right. Blue represents BA and red represents WA. Credit: DOI: 10.3390 / cancers13246347

A study led by researchers at the University of California found that the molecular characteristics of prostate cancer, called endogenous retrovirus (ERV) RNA, have prognostic value and distinguish between African and European or Middle Eastern men. I also know that I will do it. Irvine. The team also identified ERV expression signatures that may help identify patients with prostate cancer who are at greatest risk of progression, regardless of ancestor. This can also extend to the progression of other cancers.

The results of a study that “expression of endogenous retrovirus RNA in prostate tumors has prognostic value and shows differences between African Americans and European / Middle Eastern Americans” were recently published in an online journal. cancer..

Prostate cancer is the most common cancer diagnosed in men in the United States and affects millions of men around the world, but there are differences in its aggression among different ancestors. Black men are more burdened than white men. African-American patients are diagnosed at an earlier age and more advanced than Caucasian patients, and being black is an independent predictor of disease recurrence in patients undergoing radical prostatectomy. ..

“Measurement of ERV expression may help physicians predict which patients will most benefit from active monitoring or curative treatment, and also in clinically relevant prognostic models of other cancers. It can help, “says Dr. Farahnaz Rahmatpanah. .. , Associate Professor of Pathology and Experimental Medicine, UCI School of Medicine, and the corresponding author. “In the future, experiments that knock out or overexpress ERV in cells Tissue culture It may further advance our understanding of the consequences of different regulations on ERV among people of different geographic ancestry. “

To better understand Biological basis For inequality, the team investigated two potential roles of ERV. Prostate cancer.. They discovered differences in ERV expression between prostate tumors that may be associated with differences in progression mechanisms between patients of predominantly African and predominantly European or Middle Eastern ancestry, and these genes Determined a route with important functions.

A biochemical recurrence risk prediction model was developed using clinical data and ERV transcripts. This surpassed the forecast model based on. Clinical data 1 person.ERV expression signature correlated with biochemical recurrence during Prostate cancer patient One of all ancestors was revealed and ERV may help identify patients at greatest risk of progression, demonstrating the usefulness of ERV expression for studying the prostate. cancer Progression can extend to other cancers.


Hereditary mutations associated with higher risk of prostate cancer in African-American families


For more information:
Vinay Kumar et al, Expression of endogenous retrovirus RNA in prostate tumors has prognostic value and shows differences between African Americans and European / Middle Eastern Americans. cancer (2021). DOI: 10.3390 / cancers13246347

Quote: Prognostic Molecular Prostate Cancer Molecular Features, Obtained from //medicalxpress.com/news/2022-01-prostate-cancer-molecule-feature-prognostic.html on January 13, 2022 Distinguish between ancestral differences (January 13, 2022)

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