Probiotics improve nausea and vomiting in pregnancy, according to new study


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In the first study of this type, researchers at the University of California, Davis School of Medicine found that probiotics significantly improved pregnancy-related nausea, vomiting, and constipation symptoms.The survey results were published in the journal Nutrients..

Nausea and vomiting affect about 85% of pregnancies and can have a significant impact on quality of life, especially in the early stages of pregnancy.

“the cause of nausea Vomiting during pregnancy is currently unknown. Various theories have been proposed, but none are definitive, “said Albert T. Riu, lead author of the study and professor of obstetrics and gynecology.

“Nausea, vomiting and constipation during pregnancy can significantly reduce a patient’s quality of life. Nausea and vomiting during pregnancy can be uncontrollable and sometimes even require the patient to be hospitalized.” Said Liu.

Beneficial microorganisms

Probiotics are “Beneficial bacteriaThese are found in foods such as yogurt, kimchi, kefir, sauerkraut and tempeh. Probiotics can also be used as a dietary supplement. Other than vitamins, probiotics or prebiotics were the third most common, according to the National Center for Complementary and Integrated Health. I used a dietary supplement for adults.

Probiotics are thought to support a community of different microorganisms found in the gastrointestinal tract, often referred to as the “gut microbiota.”

During pregnancy, hormones such as estrogen and progesterone increase, causing many physical changes.These increases can also be changed Gut microbiotaIt affects the functioning of the digestive system and can cause unwanted symptoms such as nausea, vomiting and constipation.

Researchers have set out to determine if probiotic supplementation is beneficial to gastrointestinal function during pregnancy.

The study lasted 16 days. A total of 32 participants took probiotic capsules twice daily for 6 days and then rested for 2 days. Then they repeated this cycle.

Probiotics were commercially available and were primarily included Lactobacillus., A type of good bacteria. Each capsule contained approximately 10 billion live cultures at the time of manufacture.

Participants made 17 daily observations of symptoms during the study and a total of 535 observations for the investigator to statistically evaluate.

Researchers have found that taking probiotics significantly reduced nausea and vomiting. Nausea time (the number of hours participants felt nausea) was reduced by 16% and vomiting frequency was reduced by 33%. Probiotic intake also significantly improved quality of life-related symptoms, such as fatigue, loss of appetite, and difficulty maintaining normal social activity, as scored by the questionnaire.

Probiotics have also been found to significantly reduce constipation.

“Over the years, we’ve observed that probiotics can reduce nausea and vomiting and relieve constipation. It’s very encouraging that this study proved to be true.” Liu said. “Probiotics have also benefited many other patients who were not involved in the study,” Liu said.

New clues from gut microbiota and by-products

Participants also provided fecal specimens before and during the study. The samples were analyzed to identify the type and number of microorganisms and various by-products of digestion.

This allowed researchers to investigate whether biomarkers in fecal specimens corresponded to more severe nausea and how probiotics affected participants who started their studies with different baseline biomarkers. I was able to evaluate it.

One finding was that a small amount of bacteria carrying an enzyme called a bile acid hydrolase, which produces bile acids to absorb nutrients, was associated with more pregnancy-related vomiting. Probiotics increase bile hydrolase-producing bacteria. This may explain why the supplement reduced the levels of nausea and vomiting.

Another finding was that the levels of gut microbiota were high. Akkermansia When A. Musinifira At the beginning of the study, it was associated with more vomiting. NS Probiotics It significantly reduced the amount of these specific microorganisms and also reduced vomiting.this is Akkermansia When A. Musinifira It may be a reliable biomarker that can predict vomiting during pregnancy.

Another finding was an increase in vitamin E levels after taking probiotics. Higher levels of vitamin E were associated with lower vomiting scores.

“This study provides important insights into the effects of gut microbiota on gastrointestinal function during pregnancy. Why the gut microbiota is what we eat and the metabolites and products produced by the bacteria. Explains why it has such a big impact on our health, “says Wang. “They influence Gastrointestinal tract Not only skin health and nerve function. “

The findings are interesting, but researchers Small sample sizeFurther research is needed to confirm the effects of probiotics.

“Our previous study showed the benefits of probiotics in preventing liver inflammation. The current study may be one of the first to show the benefits of probiotics. there is. pregnancy“It will be interesting and important to further test whether probiotics can reduce the nausea and vomiting caused by chemotherapy in cancer patients,” Wang said.

There are effective treatments for nausea and vomiting in pregnancy

For more information:
Albert T. Riu et al., Probiotics improve gastrointestinal function and quality of life during pregnancy, Nutrients (2021). DOI: 10.3390 / nu13113931

Quote: Https: // According to a new study (December 3, 2021) obtained on December 3, 2021 from Probiotics. Tix improves nausea and vomiting during pregnancy

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