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    Physical activity may improve Alzheimer’s disease outcomes by lowering brain inflammation

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    Conceptual diagram of moderate mediation model. The model examines the mediating effect of inferior temporal microglial activation (PAM IT) on the relationship between physical activity and the overall cognitive outcome of the inferior temporal gyrus or synaptic integrity markers. Credits: Casaletto et al. , JNeurosci 2021

    No one argues that an active lifestyle is good for you, but it’s unclear how physical activity improves brain health, especially in Alzheimer’s disease.Benefits may come from reduced immune cell activation, according to a new study published in JNeurosci..

    Microglia, the immune cells present in the brain, activate to remove debris and foreign invaders from the brain. However, too much activation can cause inflammation, damage neurons, and interfere with brain signaling. Exercise helps reduce abnormal activation of animals, but the link has not been established in humans.

    Casalet et al. In 167, investigated the relationship between physical activity and microglial activation. senior citizen The entire spectrum of cognitive aging (mostly not dementia) as part of the Rush Memory and Aging project. Participants wore a 24-hour activity monitor for up to 10 days just prior to the annual cognitive test. Researchers measured microglial activation and the pathology of Alzheimer’s disease (AD) in postmortem brain tissue analysis. Greater physical activity was associated with lower microglial activation, especially in the inferior temporal gyrus, and the brain region was most strongly struck by AD. Physical activity had a more pronounced effect on inflammation in people with more severe AD medical conditions.

    In future research Physical activity Interventions can alter microglial activation in patients with AD.


    Does Microglia Hold the Key to Stop Alzheimer’s Disease?


    For more information:
    Microglial Correlation of Physical Activity in Later Years: Relationship with Synapses and Cognitive Aging in the Elderly, JNeurosci (2021). DOI: 10.1523 / JNEUROSCI.1483-21.2021

    Quote: Physical activity is brain inflammation obtained on November 22, 2021 from https: //medicalxpress.com/news/2021-11-physical-alzheimer-disease-outcomes-lowering.html (November 22, 2021) May improve the outcome of Alzheimer’s disease by lowering the number of days)

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    Physical activity may improve Alzheimer’s disease outcomes by lowering brain inflammation Source link Physical activity may improve Alzheimer’s disease outcomes by lowering brain inflammation

    The post Physical activity may improve Alzheimer’s disease outcomes by lowering brain inflammation appeared first on California News Times.

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