New study suggests two paths toward ‘super immunity’ to COVID-19


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New laboratory studies at Oregon Health & Science University reveal multiple paths to strong immunity from COVID-19.

In a new study, two forms of immunityBreakthrough infections Post-vaccination or natural infection Vaccination continues — provides nearly equal levels of enhanced immune protection.

A new study published online today in the journal Scientific immunology..

Dr. Fikadu Tafes, an assistant professor of molecular microbiology and co-chief author, said: Immunology of OHSU School of Medicine. “In either case, you get a surprisingly high immune response.”

This study follows the study of OHSU published in December and describes a very high level of immune response after a breakthrough infection, the so-called “hyperimmunity”. The study was the first to use multiple live SARS-CoV-2 variants to measure serum cross-neutralization from breakthrough cases.

A new study found that it doesn’t matter if someone got a breakthrough infection or was vaccinated after a natural infection. In both cases, the immune response measured in serum revealed antibodies that were equally abundant and potent (at least 10 times more potent) than the immunity produced by vaccination alone.

This study was done before the emergence of the Omicron variant, but researchers expect the hybrid immune response to be similar to the new highly infectious variant.

“Currently, there are so many viruses around us that we are likely to have a breakthrough infection,” Tafes said. “But we put ourselves in a better position by being vaccinated, and when the virus comes, we have a milder case and this hyperimmunity.”

The researchers recruited a total of 104 people, including all Pfizer vaccinated OHSU employees, 42 who were vaccinated without infection, 31 who were vaccinated after infection, and groundbreaking. Carefully divided into three groups of 31 people with infections. After vaccination.Age, gender, time management from vaccination and infection, researchers drew Blood sample Samples from each participant were exposed to three variants of the live SARS-CoV-2 virus at the Biosafety Level 3 Lab at OHSU’s Markham Hill Campus.

They found that both groups with “hybrid immunity” produced higher levels of immunity compared to the group vaccinated without infection.

Road to a unique COVID

Now that highly contagious variants of Omicron are endemic around the world, new discoveries suggest that each new breakthrough infection may end the pandemic.

Senior Co-author Bill Messer, MD, assistant professor of molecular microbiology and immunology, said: And Osu School of Medicine (Infectious Diseases)

Over time, the virus hits an ever-expanding pool of human immunity.

OHSU scientists say they haven’t tested multiple natural infections, but many, given that millions of people in the United States and around the world have not been fully vaccinated. May fall into that category. With the spread of the highly contagious Omicron variant, many previously infected unvaccinated people may face the virus again.

For that group, previous studies have revealed far more diverse levels of immune response than vaccination, Messer said.

“We can guarantee that such immunity will fluctuate. Some people get the same immunity as vaccination, but most do not,” he said. “And the only way to know who gets what immunity is in the lab. Vaccination is much more likely to guarantee a good immune response.”

Senior co-authors Marcel Curlin and MD also agreed.

“Immune from natural infections varies. Some people respond strongly and others do not,” said Curlin, an associate professor of medicine (infectious diseases) at OHSU School of Medicine and director of OHSU Occupational Health. increase. “But vaccination Join Immunity from an infection almost always gives a very strong reaction.

“These results, combined with previous studies, indicate that SARS-CoV-2 may be an almost mild endemic infection, such as a seasonal respiratory tract infection, rather than a global pandemic. I am. ”

Studies suggest that breakthrough infections create “superimmunity” against COVID-19

For more information:
Vaccination before and after Timothy A. Bates et al, SARS-CoV-2 infection provides a strong humoral response and antibodies that effectively neutralize variants. Scientific immunology (2022). DOI: 10.1126 /sciimmunol.abn8014

Timothy A. Bates et al, Convalescent and Neutralization of SARS-CoV-2 Variants with BNT162b2 Vaccinated Serum, Nature Communications (2021). DOI: 10.1038 / s41467-021-25479-6

Quote: The new study was obtained from on January 25, 2022 COVID-19 (January 25, 2022). ) Suggests two routes to “superimmunity”

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