Fencol, a natural compound abundant in some plants, including basil, may help protect the brain from the pathology of Alzheimer’s disease, researchers at the University of South Florida Health (USF Health) said. Leading preclinical studies suggest.
New study published on October 5th Frontier of Aging Neuroscience,discovered Sensing mechanism Associated with Gut microbiota It explains how Fencol reduces the neurotoxicity of the brain in Alzheimer’s disease.
New evidence shows that short-chain fatty acids (SCFAs), metabolites produced by beneficial gut bacteria and a major source of nutrients for cells in the colon, contribute to the brain. health.. The abundance of SCFA is often reduced in elderly patients with Alzheimer’s disease, the most common form of mild cognitive impairment and dementia. However, little is known about how this reduction in SCFA contributes to the progression of Alzheimer’s disease.
Intestinal SCFA, which travels through the blood to the brain, can bind to and activate free fatty acid receptor 2 (FFAR2). Brain cells It is called a neuron.
“Our study suggests that stimulation of FFAR2 sensing mechanisms by these microbial metabolites (SCFAs) may be beneficial in protecting brain cells from the toxic accumulation of amyloid beta (Aβ) proteins associated with Alzheimer’s disease. This is the first study to discover that there is, “said the principal investigator. Dr. Hariom Yadav, a professor of neurosurgery and brain repair at USF Health Morsani Medical College, directs the USF Microbiome Research Center.
One of the two characteristic pathologies of Alzheimer’s disease is a hardened deposit of Aβ that aggregates between nerve cells to form amyloid protein plaques in the brain. The other is neurofibrillary tangles of tau protein in brain cells. These conditions contribute to the loss and death of neurons that ultimately lead to the development of Alzheimer’s disease, a neurodegenerative disease characterized by loss of memory, thinking skills, and other cognitive abilities.
Dr. Yadav and his collaborators delve into molecular mechanisms to explain how interactions between the gut microbiota and the brain affect brain health and age-related cognitive decline. increase. In this study, Dr. Yadav said the research team has set out to uncover “previously unknown” functions of FFAR2 in the brain.
Researchers have found that inhibiting the FFAR2 receptor (and thus blocking the ability to “sense” SCFA and transmit intracellular signaling in the outer environment of neurons) results in abnormal accumulation of Aβ proteins. It was first shown to contribute and cause neurotoxicity associated with Alzheimer’s disease.
We then performed a large-scale virtual screening of over 144,000 natural compounds to find potential candidates that could mimic the same beneficial effects of microbiota-producing SCFAs on activation of FFAR2 signaling.Identification Natural compound Since cells in the intestine and other organs consume most of these microbial metabolites before reaching the brain through blood circulation, SCFA alternatives that optimally target neuronal FFAR2 receptors are important. Dr. Yadav said.
Dr. Yadav’s team has narrowed down the 15 major compound candidates to the strongest. Fencol, a plant-derived compound that gives basil an aromatic scent, was ideal for binding to the active site of FFAR and stimulating its signal transduction.
Further experiments in mouse models of human neuronal culture, Caenorhabditis (C.) elegans (C. elegans) and Alzheimer’s disease show that Fencol stimulates FFAR2 signaling, a microbiome sensing mechanism, resulting in excessive Aβ accumulation. And showed a significant reduction in neuronal death. Researchers have investigated more closely how Fencol regulates Aβ-induced neurotoxicity, and the compound is also known as the “zombie” cells commonly found in the brain with Alzheimer’s disease. It was found to reduce aging nerve cells.
Zombie cells stop replicating and die slowly. Meanwhile, Dr. Yadav said that they accumulate in diseased and aged organs, create a harmful inflammatory environment, signal stress and death to adjacent healthy cells, and eventually turn into harmful zombie cells. He said he would die.
“Fencol actually affects two related mechanisms of aging and proteolysis,” Dr. Yadav said intriguingly. Preclinical study find. “It reduces the formation of half-dead zombie neurons cell It also increases the breakdown of (non-functional) Aβ, so amyloid proteins are removed from the brain much faster. “
More research, including humans, is needed before starting to add a lot of extra basil to spaghetti sauces and foods to prevent dementia.
When exploring Fencol as a possible approach to treat or prevent Alzheimer’s disease, the USF Health team seeks answers to several questions. What matters is whether the fencor consumed by basil itself is more or less bioactive (effective) than the compound is administered separately in tablets, Dr. Yadav said. “Also, strong doses of either basil or fencor can make the compound brain.. ”
Atefeh Razazan et al, Activation of microbiota sensing – Free fatty acid receptor 2 signaling improves amyloid-β-induced neurotoxicity by regulating the proteolytic-aging axis, Frontier of Aging Neuroscience (2021). DOI: 10.3389 / fnagi.2021.735933
University of South Florida
Quote: The natural compound in basil is the pathology of Alzheimer’s disease (2021) obtained on October 5, 2021 from https: //medicalxpress.com/news/2021-10-natural-compound-basil-alzheimer-disease.html. May be protected from (October 5, 2014)
This document is subject to copyright. No part may be reproduced without written permission, except for fair transactions for personal investigation or research purposes. The content is provided for informational purposes only.
Natural compound in basil may protect against Alzheimer’s disease pathology Source link Natural compound in basil may protect against Alzheimer’s disease pathology
The post Natural compound in basil may protect against Alzheimer’s disease pathology appeared first on California News Times.