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    Microfluidics show promise as safer, simpler treatment option for severe neonatal jaundice

    Credit: CC0 public domain

    A study at Oregon State University’s Faculty of Engineering has led to a promising potential treatment for neonatal jaundice. This is safer, easier and more convenient than the blood transfusions currently performed on babies suffering from the most dangerous forms of condition.

    A study led by Adam Higgins, an associate professor of bioengineering, Microfluidics And bright light can correct the dangerous accumulation of blood flow in bilirubin.Bilirubin is a pigment that causes the yellow skin color associated with jaundice, And at sufficiently high levels, endangers afflicted babies, sometimes even irreversible neurological damage or even death.

    The survey results have been published at Biomicrofluidics..

    Neonatal jaundice Newborn baby, Its body is busy breaking down red blood A cell that is used in the womb and makes new cells when the baby moves out of the womb to breathe the surrounding air.

    The red color of the blood comes from a protein called hemoglobin that carries oxygen, and when those red blood cells are broken down, the liver converts hemoglobin to bilirubin. If the baby’s immature liver cannot keep up with all of the bilirubin it produces, the pigment leaks into the bloodstream before it settles on the skin, causing a yellowish appearance.

    About two-thirds of all newborns experience some degree of jaundice. This is usually a mild case. Often, it will be cleaned by itself or with minimal treatment, such as adding more water to the baby’s body.

    In other cases of high levels of bilirubin in the blood, whole body may be needed Phototherapy-Uses light to trigger a chemical reaction to produce a compound that is more easily excreted than bilirubin. And in the most serious cases, rare in the United States, it occurs in one in 100 births in many parts of the world. Infants need to replace all blood with donor blood twice, using a method called double exchange transfusion. Complex, labor-intensive and relatively dangerous procedures.

    Oregon State University research aims to provide easier and safer alternatives. The patient’s blood is treated by circulating the patient’s blood through an external device called a microfluidic photoreactor.

    Microfluidics studies how fluids behave when they pass through or are confined in microminiaturized devices with channels and chambers. On the microscale, surface forces dominate the fluid as opposed to body force. In other words, the action of fluids is very different from what is observed in everyday life.

    Using human blood in the laboratory and also using a rat model, Higgins and collaborators at the Faculty of Engineering at Oregon University of Health Sciences and Washington University have found that they are very rich in birylbin delivered via a microfluidic photoreactor. I studied the effect of LED light on blood. The photocatalytic reaction they saw is the same as the reaction made possible by whole-body phototherapy, but the bilirubin in the blood is directly targeted and more efficient.

    “Study results show that high-intensity light with a wavelength of 470 nanometers can be used to rapidly reduce bilirubin levels without perceptibly damaging the DNA of blood cells,” Higgins said. Mr. says. “Our study with cancer rats showed that 4-hour photoreactor treatment significantly reduced bilirubin levels, which is the decrease in bilirubin seen on exchange transfusions and similar time scales. Similar to the type. The mathematical model we developed suggests this new therapeutic approach we have tested. On the lab scale, it outperforms exchange transfusions on the clinical scale and is a donor. Does not require blood. “

    The next step is to scale up the device used in cancer rats to function in newborns about 10 times larger and measure blood DNA damage in preclinical animal models such as rhesus monkeys. It more closely replicates human neonatal jaundice.

    “But overall, it seems that further development of photoreactor technology could lead to promising new approaches for very high levels of treatment. Bilirubin With newborn blood, “he said.

    Higgins worked with John Lahmann, Ryan Faase, Hsuan Yu Leu, Kate Schilke, Joe Baio of the Faculty of Engineering, Steve Jacques of the University of Washington, and Brian Scottoline of the Oregon Health & Science University.


    Diagnose jaundice in a blink of an eye from a digital camera


    For more information:
    John M. Lahmann et al, Microfluidic Photoreactor for the Treatment of Neonatal Jaundice, Biomicrofluidics (2021). DOI: 10.1063 / 5.0066073

    Quote: Microfluidics was obtained from https://medicalxpress.com/news/2021-12-microfluidics-safer-simpler-treatment-option.html on December 6, 2021 for severe neonatal jaundice (121, 2021). Promising as a safer and easier treatment option (6th of March).

    This document is subject to copyright. No part may be reproduced without written permission, except for fair transactions for personal investigation or research purposes. Content is provided for informational purposes only.

    Microfluidics show promise as safer, simpler treatment option for severe neonatal jaundice Source link Microfluidics show promise as safer, simpler treatment option for severe neonatal jaundice

    The post Microfluidics show promise as safer, simpler treatment option for severe neonatal jaundice appeared first on California News Times.

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