Mathematical model of light and circadian data improves sleep timing in people with schizophrenia

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500 lux, 500-100 lux, 100-10 lux,

Typical rhythm of sleep, activity and exposure to light. (A), (d): Bright (yellow trace), activity (gray trace), 6-sulfatoximelatonin (aMT6s) acrophase (red circle) and sleep timing (horizontal gray bar). (B) and (e): Average pattern of light exposure over 24 hours. Shaded areas from white to dark gray have different light levels (> 500 lux, 500-100 lux, 100-10 lux,

Disordered sleep timing in people with schizophrenia is more likely to be associated with light exposure than with inherent biological factors.

Light exposure, application of physiology-based mathematical models to sleep timing Circadian clock data and biological markers Sleeping disorder The timing of people with schizophrenia is more likely to be related to light exposure than to the inherent biological factors.Surprisingly, the combination of mathematical models and digital health data suggested that it could be achieved by improving the normalization of sleep timing disturbances. Light availability No need to change sleep timing or sit in front of a lightbox, as recommended by current bright lights intervention Treatment.

It is well known that in people with mental disorders, including schizophrenia, sleep timing changes and contributes to sleep deprivation. Sleep deprivation is often associated with distress, poor mental health, and poor quality of life. Consistent with other studies, the current reanalysis of previously published data shows that people living with schizophrenia spend more time in bed and get up later in a more irregular pattern. I found myself sleeping. Some participants had a 24-hour sleep drift, especially during the winter months.

Whether changes in sleep timing patterns are related to changes in the biologically determined properties of the biological clock that drives sleep timing, or to behaviorally determined exposure patterns that normally synchronize the clock to the 24-hour clock. Whether it is relevant is a lively topic of debate.

An interdisciplinary team of mathematicians, circadians, sleep physiologists and psychiatrists from Sally University, Umeå University (Sweden), and King’s College London have worked together to tackle this problem.Supply unique data through Mathematical model This includes the biological factors underlying sleep timing and how environmental factors affect the body clock. exposure It is the main deciding factor.

The importance of light has long been recognized, but with current interventions, you need to sit in front of a light box that emits bright light at certain times. These interventions stipulate that people with schizophrenia need to be forced to wake up and sleep on a fixed schedule for maximum benefit. Mathematical analysis shows that this is not necessary. A much easier solution to implement is to change the pattern of light availability, with the rest of the mathematical principles of how light adjusts sleep timing.

Importantly, this approach Individual differences It can be implemented using currently available digital health technologies. Such interventions can be designed in collaboration with the patient, making it easier for the patient to stick. By increasing adherence and personalizing it, mild interventions can be a more effective way to deal with sleep disorders.

In their paper, data model fusion technology could serve as a template for how data model fusion technology can help mitigate sleep disorders in a wide range of disorders such as schizophrenia, bipolar disorder, delayed sleep phase syndrome, and dementia. Describes the implementation path for an approach. Dementia is the current focus of Sally researchers as a result of funding from the UK Institute for Dementia.

Professor Anne Skeldon of the Department of Mathematics at Sally University said:

“Our clinical framework provides a cost-effective way to help people sleep more regularly through” light availability “interventions co-designed to fit individuals into their daily lives. I am proposing. Appropriate software, light interventions can take into account individual physiological characteristics and preferences. “

Professor Derk-Jan Dijk of the Sally Sleep Research Center said:

“Combine digital health technologies to collect mathematical models and data on the effects of light. Circadian rhythm Sleep timing is a powerful approach to developing individualized interventions. “

Katharina Wulff, associate professor at Umeå University in Sweden, said:

“With these techniques at hand, the response to strong seasonal changes in sunlight here in northern Sweden is tracked by the individual and, if complementary, processed by mathematical modeling of the personalized optical regime. May be Light is required.”


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For more information:
Anne C Skeldon et al, Designing a Practical Optical Intervention by Extracting Circadian and Sleep Parameters from Longitudinal Data of Schizophrenia, Schizophrenia Breaking News (2021). DOI: 10.1093 / schbul / sbab124

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Sally University

Quote: Mathematical model of light and circadian data is available from https: //medicalxpress.com/news/2021-12-mathematical-circadian-people-schizophrenia.html on December 2, 2021 for people with schizophrenia. Improves sleep timing

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