At the beginning of medical care, doctors Maryland In his final effort to save his life, he transplanted a modified pig heart into a human patient.
Doctors at the University of Maryland Medical Center said on Monday that it was premature to know if the surgery was successful, but the patient was successful three days after the highly experimental surgery.
Nonetheless, transplants represent a step in decades of quest to someday use animal organs for life-saving surgery. According to doctors, the transplant showed that the heart of a genetically modified animal could function in the human body without immediate rejection.
Patient David Bennett, 57, knew there was no guarantee that the experiment would work, but he was dying, ineligible for a human heart transplant, and had no other choice, his son said. ..
“It was either dead or this transplant. I want to live. Bennett said the day before surgery, according to a statement from the University of Maryland School of Medicine.
There is a huge shortage of human organs donated for transplants in the United States, so scientists are thinking about how to use animal organs instead. Last year, there were just over 3,800 heart transplants in the United States, a record number, according to the United Network for Organ Sharing (Unos), which oversees the US transplant system.
“If this goes well, these organs will be infinitely supplied for suffering patients,” said Dr. Muhammad Mohiudin, director of science for the university’s animal-to-human transplant program.
However, previous attempts at such transplants, or xenografts, have failed. This is mainly due to the rapid rejection of animal organs by the patient’s body.Especially in 1984 Baby faeThe dying baby lived for 21 days with a baboon heart.
A Maryland surgeon said the difference was that a genetically-edited pig’s heart was used to remove the sugar that causes ultrafast organ rejection in its cells.
“I think you can characterize it as a watershed event,” said Dr. David Klassen, Unos Chief Medical Officer, about the Maryland transplant.
Still, Klassen warned that this is only the first tentative step in investigating whether xenotransplantation will ultimately work.
The Food and Drug Administration (FDA), which oversees xenotransplantation experiments, has allowed surgery under so-called “compassionate use” emergency permits, which can be used when life-threatening patients have no other choice.
Last September, researchers in New York conducted an experiment suggesting that these types of pigs may be promising for animal-to-human transplantation. Doctors temporarily attached the pig’s kidneys to the deceased human body and observed it begin to function.
The Maryland transplant takes their experiment to the next level, said Dr. Robert Montgomery, who led the experiment at NYU Langone Health.
“This is a truly amazing advance,” he said in a statement. “As a heart transplant recipient myself suffering from hereditary heart disease, I am excited about this news, and this news has given to my family and other patients, and ultimately by this breakthrough. I hope you will be saved. “
Karen Mashke, a researcher at the Hastings Center, says it is important to share the data collected from this transplant and then provide options to more patients. National Institute of Health.
“It is not advisable to rush into an animal-to-human transplant without this information,” Maschke said.
The surgery last Friday took 7 hours at Baltimore Hospital.
“He understands the magnitude of what has been done and really understands the importance of it,” said David Bennett Jr. of his father. “He couldn’t live, or he could last a day, or he could last a few days. That is, it’s unknown at this point.”
The Associated Press contributed to this report
Maryland Doctors First Medically Transplant Pig Hearts into Human Patients | Maryland
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