Lower airways are distinct in cystic fibrosis even at younger ages


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In the largest study of this type, the lower respiratory tract in children with cystic fibrosis (CF) is more burdensome to infect, more inflamed, and more microbially diverse than children with other diseases who also have lung problems. It turned out to be low in sex. They pointed out obvious differences in these bacterial communities in young children. This is usually before progressive lung disease has become established in CF patients.Their findings published in the journal PLOS ONE, Providers may help target specific pathogens early, treat them, and prevent more serious lung disease.

“We compared lower Airway Samples from bronchoscopy in children with CF and disease control throughout the age spectrum, and using gene sequencing to identify microorganisms, have found some common ones. Cystic fibrosis Jack O’Connor, lead author of Anne & Robert H. Lully Children’s Hospital in Chicago, said, “Pathogens begin to predominate at very early ages. This clear division from disease management in this young age group is this. Not shown by. Our findings may help to better understand the trajectory of cystic fibrosis disease and improve outcomes through early intervention. “

Chronic respiratory tract infections and inflammation lead to progressive, Obstructive lung disease It is a major cause of illness and death in people with cystic fibrosis.

A multicenter study analyzed lower respiratory tract samples from 191 patients aged 0 to 21 years (63 with cystic fibrosis). NS disease Controls included patients with a variety of conditions, including cancer, immunodeficiency, and pneumonia.By detecting a wider range of microorganisms in the lower respiratory tract using more sensitive gene sequencing instead of culture, researchers identify distinct pathogens that are more predominant at different ages in cystic patients. I was able to Fibrosis..

“Establishment of important age-related differences in lower respiratory tract bacterial communities and inflammation, especially in CF patients Early childhood, May give us an opportunity for earlier and more accurate treatment, “said Teresa Laguna, Head of Lully Children’s Department of Pulmonary and Sleep Medicine and Associate Professor of Pediatrics at Fineberg School of Medicine, Northwestern University. The doctor of medicine says. Preventing exacerbated infections may improve quality of life and extend the expected lifespan of CF patients. ”

Blood tests may lead to personalized treatment of cystic fibrosis

For more information:
John B. O’Connor et al, Bacterial community release in the lower respiratory tract of CF patients in early childhood, PLOS ONE (2021). DOI: 10.1371 / journal.pone.0257838

Quote: Lower respiratory tract is a young age obtained on October 21, 2021 from https: //medicalxpress.com/news/2021-10-airways-distinct-cystic-fibrosis-younger.html (October 21, 2021) ) But it is clear with cystic fibrosis

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