Low birth weight among IVF children not linked to infertility treatments

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A new study published today by the UCL Longitudinal Study Center in collaboration with the University of Utah shows that children who become pregnant with medically-assisted reproductive births are more likely to give birth prematurely and are at higher risk of being born smaller than naturally pregnant babies. Become.

But in a study of nearly 250,000 US families, Birth weight Pregnancy between Medical Assisted Reproductive Technology (MAR) – Including technologies such as IVF process, Artificial insemination Given the circumstances of the family, drugs that promote childbirth, and naturally pregnant children, are insignificant.

Co-authors Alina Pelikh, Ph.D. Is a researcher at the UCL Longitudinal Study Center and explains: Infertility treatment As such, our new findings underscore the importance of the underlying infertility problem of parents. Health status, And toddlers’ birth Properties like them By date of birth And whether they are twins, birth weight and gestation period. “

Researchers analyzed data from 248,000 babies born in Utah between 2009 and 2017. Its anonymized birth record is part of the Utah Population Database. They looked at information to investigate the effects of different types of fertility treatments on gestational age and the birth weight of children. Before looking at information about infant birth order and multiple births, the researchers analyzed a wealth of data on maternal health, including pre-pregnancy body mass index (BMI), blood pressure, parents’ age, and education level.

About 5% of babies became pregnant using MAR, 60% of birth-promoting drugs, 26% of assisted reproductive technology (including IVF), and 14% of artificial insemination.

The study found that children who became pregnant through MAR were 10% more likely to give birth prematurely and 9% more likely to be born smaller than naturally pregnant babies. More invasive treatments such as assisted reproductive technology and artificial insemination were more strongly associated with the adverse effects of childbirth, but babies pregnant with fertility drugs are more similar to naturally pregnant babies. I did.

“This study is made possible thanks to the secure access to Utah’s population database and anonymized data, which allows us to study births across the state, naturally or medically. I was able to understand the potential effects on newborns associated with pregnant mothers in this way. ”Co-author Dr. Ken Smith is a prominent professor of family studies and population science at the University of Utah. Said. “By comparing births from the same mother, we were able to better isolate the effects of medically-supported technology on these births.”

When researchers examined the health of the mother, the socio-economic background of the parents, and the birth characteristics of the infant, the differences in adverse birth outcomes with all types of treatment were significantly reduced.

The study then focused on a subgroup of mothers who gave birth to both MAR and spontaneously pregnant children in eight years. After considering the mother’s birth age, pre-pregnancy BMI, and infant’s birth characteristics, the difference between the pregnancy period between the siblings and the child’s birth weight disappears, and the family situation and genetic characteristics of the unobserved parent It suggests that characteristics are an important factor. Explain the link between MAR and the consequences of adverse childbirth in children.

“By comparing sibling birth results consistent with existing studies in Scandinavian countries, we found limited evidence of the effects of assisted reproductive technology on gestational age and birth weight,” Pelikh added.

Alice Goisis, Ph.D., co-author of the UCL Center for Longitudinal Studies. States: It is argued that the consequences of adverse births in infants with medically-supported assisted reproductive technology are unlikely to be caused by reproductive technology itself. “

“This new evidence can enhance existing health guidance on the risks and benefits of fertility treatment and raise awareness for families considering the use of medically assisted reproduction to aid in pregnancy. . ”


Born small does not tend to adversely affect cognitive development in in vitro fertilized babies


For more information:
“Types of Medically Assisted Reproductive Technology and Birth Results: Interfamily and Intrafamily Analysis,” Alina Pelikh, Ken R. Smith, Mikko Myrskylä, and Alice Goisis, Obstetrics and gynecology, January 6, 2022. DOI: 10.1097 / AOG.0000000000004655

Quote: Low birth weight of children with IVF not linked to fertility treatment (January 6, 2022) is https: //medicalxpress.com/news/2022-01-birth-weight-ivf-children-linked. Obtained from html on January 6, 2022

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