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    Ketamine and psychological therapy helped severe alcoholics abstain for longer in trial

    Credit: CC0 public domain

    People with severe alcohol disorders were able to refrain from alcohol longer when treated with low-dose ketamine in combination with psychotherapy in clinical trials.

    The Ketamine (KARE) trial to reduce alcohol recurrence was led by the University of Exeter and funded by the Medical Research Council.

    Phase II trials are low dose Ketamine Combined with may help prevent people from returning to heavy drinking immediately after a stop Treatment..

    Biotechnology company AWAKN Life Sciences is licensed by the University of Exeter for treatments used in clinics and partnerships. The University of Exeter and Awakun have also signed an agreement with the Devon Partnership NHS Trust to investigate NHS’s readiness for ketamine-assisted psychotherapy.

    This trial followed preliminary evidence that controlled ketamine therapy could reduce the number of recurrent alcohol dependence. Currently, there are few effective treatments for severe alcoholism that has a devastating impact on life. The KARE trial was the first to compare ketamine with or without treatment in a mental health situation.

    Was announced in American Journal of Psychiatry, The survey included 96 people Alcohol problem A person who was abstinent at the time of the trial. The team found that people who combined ketamine and treatment were completely calm and showed 87% abstinence for 162 of the 180 days during the 6-month follow-up period. This is significantly higher than any other group, indicating that this treatment may prevent recurrence. This group was more than 2.5 times more likely to remain completely abstinent at the end of the study than the placebo group.

    The team also found some evidence that ketamine and treatment could prevent drinking for more than 6 months, although the results were more complex. Patients who received ketamine had lower depression after 3 months and had better liver function than those who received placebo, regardless of whether they were used in combination with treatment.

    Professor Celia Morgan, the lead author of the University of Exeter, said: Psychotherapy It can help people refrain from alcohol longer than placebo. This is very encouraging. This result represents a significant improvement, as 3 out of 4 people usually return to heavy drinking within 6 months after quitting alcohol. ”

    Prior to the test, participants drank daily and consumed an average of 50 pints (125 units) of strong beer per week. Participants treated with ketamine drank above the recommended guidelines for a total of 5 days during the average 6-month trial period.This represents reducing the risk of death Alcohol related issues From 1 in 8 to 1 in 80.

    Professor Morgan said: “Since the pandemic began, the number of alcohol-related deaths has doubled, which means that new treatments are more urgently needed than ever before. Alcohol dependence due to liver problems. Although there were concerns about the use of ketamine in the disease, this study found that ketamine was safe and well tolerated in the clinical setting. I found that it was improving.

    “This was a Phase II clinical trial, which meant that it was conducted primarily on people to test the safety and feasibility of the treatment. Currently, an early signal that this treatment is effective. There is a need for a larger test to see if these can be confirmed. Effect.

    Professor Celia Morgan of the University of Exeter discusses the results of a ketamine (KARE) trial to reduce alcohol recurrence. Credit: AWAKN Life Sciences

    “We certainly do not recommend taking ketamine outside the clinical context. Street drugs carry obvious risks. As with the expertise and support of clinical staff, low ketamine. The combination of dose and proper psychotherapy is important .. This combination has shown the benefits that are still seen after 6 months in a group of people who do not work with many existing treatments. “

    Professor Anne Lingford-Hughes of Imperial College London is a co-author of this study. She states: “The KARE trial is an important step in exploring new approaches to meet the vast unmet treatment needs associated with alcoholism. This trial is an alcohol-related experience that ketamine therapy has experienced with alcoholism. It shows that it could be one way to undo the harm. Many. “

    A study of the experiences of 12 KARE study participants was previously published in another paper. Psychiatry frontier, Researchers conducted a detailed interview.

    Merve Mollaahmetoglu, the lead author of the University of Exeter, said: It can stimulate an “observer’s condition” similar to that described in Mindfulness, and may help the patient take a step back and think about their thoughts and feelings. Participants said this experience helped change their relationship with alcohol. ”

    For one of the trial participants interviewed, not thinking too much about their problems and deepening their connection with the world around them seemed to influence their relationship with alcohol. Worries and small things can help improve your relationship with alcohol. I think I used alcohol as a self-medication and as a blocking and avoidance mechanism, so I feel these problems are less common, or at least less important. It means that you are less motivated to drink. ”

    Many of the participants considered the combination of ketamine and treatment to be a beneficial combination. One interviewee said, “Not only did I have a life-changing and mind-changing experience, but the therapist took me some new ideas and made me think differently. You are you. You change things in such an intense and life-changing way that you are given a new idea and someone knows to give you something to replenish it. ”

    Anthony Tennyson is the CEO and research rights holder of AWAKN, a biotechnology company that develops and provides psychedelic drugs (pharmaceuticals and treatments) for the treatment of addiction. “We are very pleased that such promising results have been seen in long-stagnation therapeutic areas, with few or substandard options available to so many people. It means that ketamine is a licensed drug. Now we can offer this treatment in our clinic and through partnerships. This is a fundamental change in the alcoholism treatment industry. ”

    Patrick Chinnery, MRC Clinical Director, said: It is important because it helps humans to better understand addiction and find more effective treatments that can prevent recurrence. “

    This study was led by the University of Exeter in collaboration with Imperial College London and University College London.

    The paper “Ketamine Auxiliary to Psychotherapy Based on Prevention of Recurrence as a Treatment of Alcohol Use Disorders” is published today. American Journal of Psychiatry..

    A paper on the participants’ experiences entitled “This has changed my life: Qualitative Research of Patients” is the experience in clinical trials of ketamine treatment. alcohol “Usage failure” was posted Psychiatry frontier August 16th.


    Ketamine therapy quickly relieves depression and suicidal ideation


    For more information:
    Ketamine, an adjunct to psychotherapy based on prevention of recurrence as a treatment for alcohol use disorders, American Journal of Psychiatry (2022). DOI: 10.1176 / appi.ajp.2021.21030277

    This has changed my life: patient qualitative research, Psychiatry frontier (2022). DOI: 10.3389 / fpsyt.2021.695335 , www.frontiersin.org/articles/1… syt.2021.695335/full

    Quote: Ketamine and psychotherapy helped people with severe alcoholism abstain longer in the trial (January 11, 2022).

    This document is subject to copyright. No part may be reproduced without written permission, except for fair transactions for personal investigation or research purposes. Content is provided for informational purposes only.

    Ketamine and psychological therapy helped severe alcoholics abstain for longer in trial Source link Ketamine and psychological therapy helped severe alcoholics abstain for longer in trial

    The post Ketamine and psychological therapy helped severe alcoholics abstain for longer in trial appeared first on California News Times.

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