Growing blood vessels are multitasking specialists. The cells in the wall need to not only divide, but also germinate in new directions, learning to specialize, and eventually become part of veins, arteries, or lymph vessels. Professor Karina Janiv of the Weizmann Institute of Science and her team begin to learn how cells solve these multiple challenges, shedding new light on cancer treatment, heart regeneration, and other conditions associated with vascular growth. I came up with an amazing answer that I could hit. ..
Dr. Ayelet Jerafi-Vider, a former research student in Yaniv’s lab in the Department of Biological Regulation, has decided to follow along with Dr. Ivan Bassi, Noga Moshe, and Yaara Tevet. Cell division On the wall of growth Blood vessels With a transparent zebrafish embryo.To this end, scientists have created transgenic fish with endothelial nuclei. cell-With cells lined up on the inner wall of blood Lymphatic vessels— Lights up by color change: green when cells are dividing, red when not dividing. They were surprised to find that the nucleus was always red whenever the cell began to germinate from the mothership. This meant that cell division was temporarily interrupted, apparently preventing the cells from “distracting” during migration. Only when the cells settled in the right place did their nuclei turn green. That is, the cells have begun to divide.
Yet another surprising finding awaited scientists when they investigated which genes regulated the growth of blood vessels. As expected, they saw significant expression of a growth factor called VEGFC when cells began to germinate and migrate. However, this growth factor caused the expression of genes that temporarily block cell division, such as the well-known tumor suppressor p53. Cells resumed division when they entered regions with low VEGFC levels, resulting in reduced p53 levels. The p53 gene, sometimes referred to as the “guardian of the genome,” has been widely studied in cancer, but current research reveals a whole new role in enabling cell germination during vascular growth. ..
“We have discovered a beautiful mechanism — the same Growth factors Inducing germination also temporarily blocks the cell cycle, allowing cells to germinate and migrate without being busy with division. This is a complex and demanding process, “explains Yaniv.
Scientists then used drugs commonly used in cancer chemotherapy to force the cell division of growing blood vessels to stop. This promoted the growth of blood vessels, germinated randomly, and did not specialize in different blood vessel types.Their messy entanglement resembled chaotic Blood vessel growth It often wraps and penetrates Cancerous tumor..
“Our findings suggest that certain chemotherapeutic agents may solve one problem: block cancer cell division, cause another problem, and tumors. It stimulates the growth of blood vessels that can support the survival of the cancer, “says Yaniv. “If this is true in future studies, it may indicate new ways to make chemotherapy more effective.”
If this concern is validated by further studies, it should be taken into account when designing cancer treatments to prevent the growth of new blood vessels after chemotherapy. On the other hand, understanding how vascular growth is precisely regulated and controlled may one day help promote this growth if tissue regeneration or regeneration is required. heart attack Or stroke.
The study was published in Cell report..
Cell cycle arrest induced by Ayelet Jerafi-Vider et al, VEGFC / FLT4 mediates germination and differentiation of venous and lymphatic endothelial cells. Cell report (2021). DOI: 10.1016 / j.celrep.2021.109255
Weizmann Institute of Science
Quote: Block distractions: How growing blood vessels do it all (October 5, 2021), https: //medicalxpress.com/news/2021-10-blocking-distraction-blood-vessels.html 2021 Obtained October 5, 2014
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