Studies show that poor cardiovascular health can impair blood flow to the brain and increase the risk of dementia, but a new study led by the University of California, San Francisco shows poor mental health. It has been shown that it can adversely affect cognition.
This study adds a set of evidence linking depression to dementia, but while most studies point to that link in later years, the UCSF study found that depression Early adulthood May lead to cognitive decline after 10 years Cognitive decline old age.
The research will be published at Alzheimer’s Disease Journal September 28, 2021.
Researchers use innovative statistical methods to Depressive symptoms Approximately 15,000 participants aged 20-89 are divided into three life stages: older, middle-aged, and younger adults. Next, applying these predicted trajectories, in a group of about 6,000 elderly participants, the odds of cognitive impairment were 73% higher in those estimated to have high symptoms of depression in early adulthood, We found that people with an estimated high depression were 43% higher. Symptoms of later years.
These results were adjusted for depressive symptoms at other life stages and differences in age, gender, race, educational background, classification of obesity index, diabetic history, and smoking status. For the symptoms of middle-aged depression, researchers found an association with cognitive impairment, which was ignored when adapted to depression at other life stages.
Excessive stress hormones can impair your ability to create new memories
“Several mechanisms explain how depression increases the risk of dementia,” said Willa Breno, lead author of the University of California, San Francisco School of Psychiatry and Behavioral Sciences and the Weil Neuroscience Institute. Dr. Witz (MPH) said. “In it, hyperactivity of the central stress response system increases the production of the stress hormone glucocorticoid, causing damage to the hippocampus, a part of the brain that is essential for the formation, organization and preservation of new memory. There is something that causes it. “
Other studies have linked depression to hippocampal atrophy, and one study has shown that women have a higher rate of volume loss, she said.
In estimating depressive symptoms across each life stage, researchers pooled data from younger participants with data from approximately 6,000 older participants and predicted mean trajectories. These participants, who lived at home with an average age of 72 at the start of the study, were enrolled in the Health Aging and Body Composition Study and the Cardiovascular Health Study. They were tracked for up to 11 years, annually or semi-annually.
U-shaped curves add reliability to the predicted trajectory
Although the assumptions were used, the authors stated that a longitudinal study across the life course was not completed. “It seems to be depression Symptoms The orbit fits into a U-shaped curve, similar to the age-related trends in other studies. ”
Participants were screened for depression using a tool called CESD-10, a 10-item questionnaire that assesses symptoms over the past week.Symptoms of moderate or severe depression were found in 13 percent Young adult, 26% of middle-aged adults and 34% of the elderly.
Approximately 1,277 participants were diagnosed with cognitive impairment after neuropsychological tests, evidence of global decline, records of dementia drug use, or hospitalization for dementia as a primary or secondary diagnosis. rice field.
“In general, we found that the greater the depressive symptoms, the lower the cognitive ability and the faster the rate of decline,” said Brenowitz, who is also a member of the UCSF Epidemiology and Biostatistics Department. increase. “We have found that older people who are presumed to have moderate or severe depressive symptoms in early adulthood experience cognitive decline for more than 10 years.”
It is important to recognize its role in cognitive aging, as up to 20% of the population suffers from depression for life, said a senior author of the Department of Psychiatry and Behavioral Sciences, Epidemiology and Biostatistics, University of California, San Francisco. One Dr. Christine Jaffe said. “We need to do more work to confirm these findings, but in the meantime, we need to screen and treat them. depression For many reasons. ”
University of California, San Francisco
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