Grape seed extract found to extend lifespan of old mice


0.05; * P <0.05; ** P <0.01; *** P <0.001; **** P

Figure 1: characterization of GSE’s ability to eliminate senescent cells. Quantification of aging PSC27 cell survival by SA-β-Gal positivity. GSE was applied to the medium in increasing concentration. CTRL, control (proliferation) cells; SEN, senescent cells; NS, not important. The P-value was calculated by one-way ANOVA using Tukey’s multiple comparison test. b, Representative images showing SA-β-Gal staining after treating PSC27 cells with different concentrations of GSE. Scale bar, 20 μm. The data represent three independent experiments. DMSO, dimethyl sulfoxide. c, Survival analysis of control and aging PSC27 cells treated with GSE (concentrations of 0.3750, 0.7500, 1.8750, 3.7500, 7.5000 and 15.0000 μgml-1, respectively). Data are shown as mean ± sd and were obtained from 3 biological replications (n ​​= 3 independent assays). The P-value was calculated by a two-sided t-test. d, Measurement of in vitro viability over time during control and treatment of aging PSC27 cells with GSE (3.75 μg ml-1). Data are shown as mean ± sd and were obtained from 3 biological replications (n ​​= 3 independent experiments). The P-value was calculated by a two-sided t-test. Flow site of control and aging PSC27 cells after treatment with e, Annexin V–FITC and propidium iodide (PI) kit and 4,6-diamidino-2-phenylindole (DAPI) staining to determine the degree of apoptosis Cytometric measurement. Q1 to Q4, quartiles 1 to 4. f, Percentage of viable cells (Q4, PI-annexin V-) and apoptotic cells (Q2 and Q3, PI + annexin V + and PI-annexin V +, respectively) in a control or aged population treated with vehicle or GSE for 3 years Comparative quantification d (n = 3 biologically independent assays). The P-value was calculated by a two-sided t-test. g, Measurement of the fluorescence signal of MitoSOX Red, a mitochondrial superoxide indicator in PSC27 cells under various conditions. The P-value was calculated by a two-sided t-test. h, High resolution mass spectrum showing total ion chromatogram (TIC) and base peak chromatogram of GSE after running HPLC-ESI-QTOF-MS. Unless otherwise stated, cells were subjected to relevant analysis 3 days after GSE treatment in culture conditions. cps, count per second. The bar graph and regression curve data are shown as mean ± sd and represent three biological replicas. NS, P> 0.05; * NS

A team of researchers from many institutions in China and the United States have found that injection of procyanidin C1 (PCC1), a chemical found in grape seed extract, into older mice increases lifespan.In their paper published in the journal Natural metabolism, The group describes the association between PCC1 and extended lifespan in mice, and the experiments they performed using the material.

Scientists have been for years Aging process.. Once you understand Mitigation efforts You can slow down or stop the process so that people can live longer and live in a healthier way as they get older. In this new initiative, researchers screened 46 plant extracts looking for anti-aging capabilities. They came across PCC1. Initial tests during screening showed a reduction in the number of senescent cells in the human prostate. Such cells are known to contribute to aging. Intrigued by their results, the researchers tested it further. They prevent senescent cells from contributing to inflammation at low doses, High dose Killed them completely without harming other cells.

The team then injected PCC1 into 171 mice, 91 of which were considered old. They found that this increased the overall lifespan of mice by an average of 9% and the remaining lifespan by an average of 60%. Researchers have also found that young mice were injected with the extract chemicals for four months, which improved their fitness.Then they injected the mice they had Cancerous tumor When given in combination with chemotherapy, it has been found to help shrink the tumor. They also found that it did the same with human tumor cells transplanted into mice.

Researchers, in all tests, Normal cellsThis suggests that PCC1 is a promising treatment for a variety of conditions and can very well reduce some of the adverse effects of aging. They conclude that more work is needed to further test its effectiveness and ensure that it does not cause negative side effects.

Inhibits KGA-dependent glutaminolysis in mice found to eliminate senescent cells

For more information:
Qixia Xu et al, flavonoid procyanidin C1, has senotherapy activity and prolongs the lifespan of mice, Natural metabolism (2021). DOI: 10.1038 / s42255-021-00491-8

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