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    Genetic study suggests syphilis is back, and it’s global

    25% of genome location) genome. The size of the circle corresponds to the total number of genomes (categorized) and the color corresponds to the country. The coordinates of the country used are the positions of the center of gravity of the country, except for Russia (where the center of gravity of the Republic of Tuva is used) and Mexico (where the location of Mexico City is used). Map tiles by Stamen Design (CC-BY 3.0), map data by OpenStreetMap (ODbl). b, Temporal distribution of samples by country. The size of the circle indicates the number of samples for the year. Three samples from Baltimore (USA) had uncertain sampling dates (1960–1980) and were set to 1970 to plot the dates b and e. Genomes derived from passage variants of the Nichols-1912 isolate, or genomes with uncertain collection dates, are not shown in the plotted timelines (b, e). c, the total number of samples by country. d, Relative percentage of country samples corresponding to each TPA strain (if there was only one sample per country, this would indicate the corresponding strain). e, Temporal distribution of samples by TPA strain. f, Total number of samples by TPA strain. Credit: DOI: 10.1038 / s41564-021-01000-z” width =”800″ height =”530″/>

    Figure 1: Global distribution of 726T. p. Globus pallidus partial genome. Map of a sampled country of a, 726 partial (> 25% of genome location) genome. The size of the circle corresponds to the total number of genomes (categorized) and the color corresponds to the country. The coordinates of the country used are the positions of the center of gravity of the country, except for Russia (where the center of gravity of the Republic of Tuva is used) and Mexico (where the location of Mexico City is used). Map tiles by Stamen Design (CC-BY 3.0), map data by OpenStreetMap (ODbl). b, Temporal distribution of samples by country. The size of the circle indicates the number of samples for the year. Three samples from Baltimore (USA) had uncertain sampling dates (1960–1980) and were set to 1970 to plot the dates b and e. Genomes derived from passage variants of the Nichols-1912 isolate, or genomes with uncertain collection dates, are not shown in the plotted timelines (b, e). c, the total number of samples by country. d, Relative percentage of country samples corresponding to each TPA strain (if there was only one sample per country, this would indicate the corresponding strain). e, Temporal distribution of samples by TPA strain. f, Total number of samples by TPA strain. Credit: DOI: 10.1038 / s41564-021-01000-z

    The most comprehensive genomic study of syphilis to date has mapped the recent resurgence of syphilis around the world.

    According to a study published in, the worldwide spread of syphilis has been widespread, especially within the last 20 years. Nature microbiology..

    Researchers at the London School of Hygiene and Tropical Medicine (LSHTM), Welcome Sanger Institute, UK Health and Security Agency, and their collaborators have mapped recent recurrences of the disease worldwide. They found nearly identical samples of syphilis across 14 countries. The world’s syphilis population consists of two strains, SS14 and Nichols.

    A detailed analysis of these strains provides important insights into the genetic diversity of syphilis that affects vaccine design and antimicrobial resistance.

    Syphilis is one of the most common sexually transmitted diseases (STIs) in the world, with about 6 million infections each year. Treponema pallidum is easy to treat, but symptoms may diminish or not appear at all before you notice the infection. If left untreated, syphilis can cause serious long-term health problems.

    Syphilis infections that occur during pregnancy can be transmitted and cause in children Congenital syphilis.. This is the second leading cause of stillbirth in the world and can have serious developmental consequences for children carried to maturity. It can be prevented by early screening and treatment during pregnancy. Congenital syphilis is more common in countries without such screening programs.

    In this welcome-sponsored study, researchers at LSHTM and the Welcome Sanger Institute coordinated the collection of 726 syphilis samples from 23 countries. This includes high sample areas such as the United States and Western Europe, as well as low sample areas such as Central Asia, Australia and Africa.

    The Sanger Institute sequenced the genome of each sample and performed phylogenetic and cluster analysis to map the world’s syphilis populations.

    DNA changes occur at known predictable rates over time, allowing the establishment of ancestral relationships between different sequences. The team found that all samples were from two deeply branched strains, Nichols and SS14. Both strains are currently circulating in 12 of the 23 sampled countries, and 14 of these countries had approximately the same sample.

    Dr. Matthew Beale, the first author of the Wellcome Trust Sanger Institute’s research, said: T. probably as a result of the HIV / AIDS crisis. It shows that the population of pallidum has decreased significantly. A concern from a public health perspective is that the presence of nearly identical samples in many countries suggests that the disease is infected. Regularly internationally. Syphilis is back and it’s global. “

    The incidence of syphilis decreased from the 1980s to the 1990s, partly due to safer sexual activity triggered by the HIV / AIDS epidemic. However, syphilis has increased again in recent decades and has risen by more than 300% in some countries since 2010. Syphilis affects imbalances in men (MSM) who have sex with men in some countries. For example, 90% of UK cases of syphilis in 2017 were included in MSM. ..

    Dr. Helen Pfeiffer, senior author of the UK National Security Agency’s (UKHSA) paper, said: In recent years, the proportion of cases diagnosed during the incubation period of men who have sex with men (MSM) is high, and there is a risk of congenital syphilis, so there is concern about an increase in syphilis between the opposite sex. Anyone who has sex with a new or casual partner should. Take a test with a condom — STI can have serious consequences for an individual’s health and the health of their current or future sexual partner. “

    This study is a valuable resource for understanding the genetic diversity of Treponema pallidum, which affects vaccine design and drug resistance. Many of the sequenced samples were resistant to macrolides, a class of antibiotics used to treat many STIs, but were resistant to the most common treatment for syphilis, benzathine benzylpenicillin. There wasn’t. The syphilis vaccine should be tailored to the most common strains of Treponema pallidum currently in circulation.

    Professor Nicholas Thomson, senior author of research at the LSHTM and the Wellcome Trust Sanger Institute, said: Syphilis genomics research and these data provide a solid foundation for future research. Coupled with the recent ability to incubate T. pallidum in the lab, syphilis is rapidly becoming an urgent public, increasing activity in this area. Health problems.”


    2,022 U.S. infants born in 2020 reported with congenital syphilis


    For more information:
    The worldwide outbreak of the Treponema pallidum strain, including Matthew A. Beer, reveals the recent spread and spread of modern syphilis, Nature microbiology (2021). DOI: 10.1038 / s41564-021-01000-z

    Quote: Genetic studies suggest that syphilis is back, global (November 29, 2021), November 29, 2021 https://medicalxpress.com/news/2021-11-genetic Obtained from -syphilis-global.html

    This document is subject to copyright. No part may be reproduced without written permission, except for fair transactions for personal investigation or research purposes. Content is provided for informational purposes only.

    Genetic study suggests syphilis is back, and it’s global Source link Genetic study suggests syphilis is back, and it’s global

    The post Genetic study suggests syphilis is back, and it’s global appeared first on California News Times.

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