A team of Newcastle scientists and clinicians have developed pioneering tests that reliably predict the spread or recurrence of the most deadly forms of skin cancer.
Technological advances came when we made scientific advances in understanding the mechanisms of skin cancer growth.
The test, led by Professor Penny Robert of Newcastle University in the United Kingdom, works with the university’s spin-out company AMLo Biosciences to reassure early-diagnosed patients. melanoma..
A test called AMBLor can be applied to a standard biopsy during removal of primary melanoma to identify patients at low risk of recurrence or spread of the disease.
With the support of the National Institute for Health Research (NIHR), we have developed a offering and, in collaboration with AMLo Biosciences, have access to a referral service that allows us to slice a patient’s melanoma. Post to lab for analysis..
This test identifies the true risk of disease progression in patients and is more about the risk of spreading the disease to those diagnosed with early-stage melanoma without ulcers (accounting for about 75% of all new diagnoses). Provides accurate information.
Scientists are now demonstrating and researching the skin mechanisms that underpin the test. British Journal of Dermatology..
Melanoma is increasing worldwide, with more than 16,000 people diagnosed with cancer in the United Kingdom and more than 96,000 in the United States each year.
In a new study, the authors explain how early-stage melanoma at risk of diffusion secretes the protein AMBRA1 and the growth factor TGFβ2, which causes the reduction or downregulation of the protein AMBRA1 and loricrin found in tumor-overlapping skin. doing. The growth factor TGFβ2 also causes the loss of claudin 1, impairing skin integrity and promoting ulcer formation.
Professor Penny Lovat, Professor of Cellular Skin Oncology at Newcastle University and Chief Scientific Officer at AMLo Biosciences, explains: The upper layer of the skin. The loss of these proteins creates gaps that cause the mortar to crumble on the wall. This can cause the tumor to spread and eventually become an ulcer. This has been found to be a process associated with high-risk tumors.
“A new understanding of this biological mechanism underpins the tests available to us.”
49-year-old Cory Inglis lives on the South Coast and is about to be used for a standard biopsy after being diagnosed with melanoma of the back. “When I sit down with a dermatologist after the first excision, I hear it was a melanoma, not a mole. You are in a state of horror. It is overwhelming. There is a lot of information at that moment. Is a very mysterious technical term. You ask yourself, what does that mean to me? Such a test that provides the result that melanoma is low or at risk. Once available, your medical team will be able to communicate, providing information in an easy-to-understand way, and importantly, helping them make the right subsequent decisions for you. ..
“Tests that show a really low risk of tumors, like AMBLor, greatly reduce anxiety in situations that are already very stressful.
“Patients will understand what low-risk outcomes mean. If the outcomes are at risk, it will have a significant number of interactions with the dermatology team over a five-year period. Fully justified. A dermatology team that provides more information about melanoma. “
Professor Penny Lovat said: Increase appointments for patients identified as low risk and save NHS time and money. “
Phil Brady, Chief Operating Officer of the British Skin Foundation, said: While increasing efficiency and reducing NHS costs. “
Professor Nick Revel, a dermatologist, spokesman for the British Skin Foundation, and not involved in the study, said: I have to go to the hospital frequently for tests. This British Skin Foundation jointly funded study is an important step towards making post-melanoma care more personal. “
Currently, the primary tumor is surgically resected, and pathologists are studying biopsies under a microscope to determine the stage of skin cancer and the risk of its spread (metastasis). Patients are followed up in the clinic for up to 5 years, even if defined as low risk. And these patients can be identified by the test.
AMBRA1 and Lolicon Test are UKAS accredited and already available through a private referral service from spin-out company AMBLo Biosciences. This test sends a standard biopsy tissue section to the lab for analysis at the post. The Newcastle team has also submitted a test application to make it available on the NHS.
I. Cosgarea et al, transforming growth factor-β2-melanoma secretion causes loss of epidermal AMBRA1, threatening epidermal integrity and promoting tumor ulcers. British Journal of Dermatology (2021). DOI: 10.1111 / bjd.20889
Quote: The first melanoma test (January 14, 2022) that provides peace of mind that the risk of cancer spread is https: //medicalxpress.com/news/2022-01-melanoma-reassurance-cancer.html Obtained from January 14, 2022.
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