According to a study published Thursday, young children may be able to overcome peanut allergies if treated early enough.
Researchers gave an increasing amount peanut Protein powder for groups of toddlers to increase resistance to peanuts. Two and a half years later, nearly three-quarters were able to tolerate the equivalent of 16 peanuts without an allergic reaction.Half a year later process It stopped, but one-fifth still had the same resistance.
This approach Youngest children People with mild allergies were reported in The Lancet magazine on Thursday.
Dr. Stacie Jones, a research co-author of the University of Arkansas Health Services Research, suggests that the findings suggest that there is an “window of opportunity” early in life where treatment can have lasting effects. increase. But she said more research is needed to determine how long the effect lasts.
treatment of Peanut allergy Already present, but only approved for ages 4 and older, it provides protection against accidental exposure to small amounts of peanuts. Children are still supposed to avoid eating nuts and carry EpiPen or other medications for allergic reactions. I also use peanut powder, but protection ceases when the child stops treatment.
Jones and her colleague Young children See if your immune system can change if treated at an earlier age. She has helped lead the study of Palforzia in Aimmune Therapeutics, the current treatment, and has consulted with the company.
About 2% of children in the United States have a peanut allergy, which can cause serious reactions and can be a constant source of trouble for parents. Some children overcome allergies, but most children have to keep avoiding peanuts for the rest of their lives. To prevent the development of allergies, health experts in recent years recommend that parents give their babies foods containing peanuts at an early stage.
A new government-sponsored study involved 146 children aged 1 to 3 in the United States. They were given daily oat flour, a peanut powder or dummy powder mixed with food. At the end of treatment, 71% of those who got peanut powder were able to tolerate the equivalent of 16 peanuts. After 6 months, 21% was still possible. In the dummy powder comparison group, 2% were able to tolerate 16 peanuts at the end of the treatment and after 6 months.
Most children responded during treatment and most were mild to moderate. Some of the peanut groups needed treatment with EpiPen.
Dr. Joyce Sue, an allergist at Brigham and Women’s Hospital in Boston, who was not involved in the study, said the study “really supports what we have been thinking for a while in this area.” Stated. “Children’s immune system is generally more adaptable the younger they are.”
Sue’s Clinic offers peanut protein allergy treatments for children over 4 months of age.Like Parforzia, Sue said it was intended to protect against accidental ingestion, and it was Children I’m still supposed to avoid peanuts. She said there was a lack of strong data on the treatment of infant peanut allergies. infant..
In the commentary published in the study, other allergy experts noted the wide availability of peanuts. powder Used in research. They said that under the guidance of an allergy expert, treatment is a reasonable option ready for actual implementation.
Dr. John Kelso, allergy Experts at the Scripps Clinic in San Diego said the findings should give doctors the confidence to try treatments for young children and provide them to their parents. However, he said it is not yet clear if there is a limit to the tolerance or how it will change over time.
“We still need to be careful about thinking of this as a cure,” he said.
Efficacy and Safety of Oral Immunotherapy in Children 1-3 Years With Peanut Allergy (Immune Resistance Network IMPACT Trial): Randomized Placebo Controlled Trial, Lancet (2022). DOI: 10.1016 / PIIS0140-6736 (21) 02390-4 , www.thelancet.com/journals/lan… (21) 02390-4 / fulltext
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