COVID-19-vaccinated kidney transplant recipients are especially vulnerable to emerging SARS-CoV-2 variants

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Credit: AIXabay / CC0 public domain

Kidney transplant recipients tend to cause impaired antibody response to new SARS-CoV-2 variants after standard double doses of COVID-19 vaccination. CJASN.. This also applies to transplant recipients who show a detectable antibody response to the original SARS-CoV-2 strain in a commercial assay.

because liver Transplant recipient Due to the high risk of SARS-CoV-2 infection and more severe COVID-19 disease, SARS-CoV-2 vaccination is highly recommended for these patients. However, studies have shown that kidney transplant recipients have a lower antibody response after SARS-CoV-2 vaccination than healthy individuals. Most of these studies were conducted when the SARS-CoV-2 wild-type and B.1.1.7 (alpha) strains were the predominant mutants, so the findings are of concern for new mutants B.1.351. It is unclear if it will lead to the current situation of (beta). ) And B.1.617.2 (Delta).

To investigate, a team led by Claudius Speer, MD (Heidelberg University Hospital, Germany), has 173 kidney transplant recipes with different SARS-CoV-2 vaccination schedules between December 2020 and June 2021. We conducted a prospective two-center study of ent and 166 healthy controls.

Few kidney transplant recipients developed neutralization after vaccination antibody Against SARS-CoV-2 than a healthy control. After the second vaccination Dose, anti-S1, anti-receptor binding domain, and surrogate neutralizing antibodies (all different types of antibodies against various aspects of SARS-CoV-2) are 30%, 27%, and 24% of kidney transplant recipients. It was detectable at. Each. This was compared to 100%, 96%, and 100% of healthy controls.

Neutralization to B.1.1.7 (alpha) was detectable in all 36 of the 173 kidney transplant recipients who showed an antibody response to the original SARS-CoV-2 strain.However, these 36 kidney transplant recipients are their Antibody reaction Only 64% and 67% showed neutralization to B.1.351 (beta) and B.1.617.2 (delta), respectively, for the new mutants after vaccination. Neutralization for different variants was significantly higher in healthy controls and all individuals showed neutralization for all tested variants.

“Most of the kidney transplant recipients are the standard vaccination regimens currently used in the healthy general population, properly from the new variants B.1.351 (beta) and B.1.617.2 (delta). I found it unprotected, “Dr. .Speer. “Additional vaccines to kidney transplant recipients to maintain high levels of neutralizing antibodies, especially if B.1.617.2 (delta) or other variants that partially escape neutralizing antibodies are widespread. Inoculation seems necessary. “

An accompanying editorial states that additional strategies other than booster shots are needed to protect kidney transplant recipients who do not respond to standard double-dose vaccine therapy. “In the absence of seroconversion, the use of anti-SARS-CoV-2 monoclonal antibodies may be a solution to protect this vulnerable population from the emergence of variant of concern,” the author writes. increase.

An accompanying patient voice editorial provides a patient perspective living with the kidneys Transplant 25 years.


Immune response after COVID-19 vaccination in kidney transplant and dialysis patients


For more information:
“Neutralization of SARS-CoV-2 variants of concern in kidney transplant recipients after standard COVID-19 vaccination”. CJASN, DOI: 10.2215 / CJN.11820921

“Protection against SARS-CoV-2 mutants by COVID-19 vaccination in kidney transplant recipients”. CJASN, DOI: 10.2215 / CJN.14881121

“Honorable Continuing Battle-Protecting Organ Transplant Recipients from COVID-19 in the Age of Disinformation” CJASN, DOI: 10.2215 / CJN.15071121

Quote: COVID-19 Vaccinated Kidney Transplant Recipient is the new SARS-CoV obtained from https: //medicalxpress.com/news/2021-12-covid-vaccinated-kidney on December 22, 2021. -Especially vulnerable to 2 variants (December 22, 2021). -Porting-Recipient-vulnerable.html

This document is subject to copyright. No part may be reproduced without written permission, except for fair transactions for personal investigation or research purposes. Content is provided for informational purposes only.

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