Best way to boost the immune system after a single Janssen vaccination is with mRNA booster

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An immune response unique to SARS-CoV-2S. Credit: DOI: 10.1056 / NEJMoa2116747

Coronavirus booster shots have a better immune response to COVID-19 than a single dose of the vaccine. The mRNA booster is most effective when given Janssen. These are the result of collaborative research between several organizations, including the Leiden University Medical Center (LUMC).The survey results are published in New England Journal of Medicine..

Due to the circulation of new coronavirus variants and weakened immunity Immune system After a single vaccination with Janssen, use the Pfizer and Moderna mRNA vaccines. This is compared to the second Janssen dose. amplifier Jeez. Researchers Virus infection Communication based on observations made in the SWITCH study (multicenter collaborative study including LUMC, UMC Groningen, Amsterdam UMC, coordinated by Erasmus MC).

Healthcare workers at various academic hospitals receiving a single dose of Janssen vaccination I was invited to participate in the study in the spring of 2021. Participants were either randomly assigned boosters from Janssen, Moderna, and Pfizer, or were not assigned boosters. In this study, we investigated the effects of booster shots given with various vaccines on the response of the immune system.

Clean up the coronavirus

Researchers have investigated the effects of booster vaccines on antibodies and immune cells, two specific areas of the immune system. Antibodies are important in preventing coronavirus infection, and immune cells ensure that the coronavirus is cleared as soon as it enters the body. When receiving booster shots with Janssen, Moderna, or Pfizer, both increases were observed. However, the increase was greater for Moderna and Pfizer than for the Janssen vaccine.

Antibody level

Janssen was the only shot approved for a single dose and protected 85.4% of subjects vaccinated from severe COVID-19 28 days later. This level of protection was acceptable, but antibody levels after a single dose of Janssen were lower than after a single dose of the mRNA vaccine. “It is important that the emergence of coronavirus variants has shown that additional vaccines work well after one shot of Janssen,” said Leo Visser, a professor of infectious diseases and coordinator of LUMC’s SWITCH study. I am. Not only is “mixing” with Janssen more effective than “matching”, it’s also well tolerated.

Future studies will demonstrate the added value of boosters for severe illness. Researchers say discussions about the need for booster shots should take into account global inequality in target groups, mutant circulation, and access to vaccines. Boosting with available vaccines is better than not doing boosting at all.

Policy rationale

The SWITCH study was a randomized controlled trial involving 461 Health care workers Inoculated with Janssen vaccine in May or June 2021. In Leiden, 80 LUMC staff participated. This study has served as the basis for policy by the Health Council and national outbreak management teams. SWITCH is made possible thanks to funding from ZonMw.


Experts eliminate confusion about COVID-19 boosters


For more information:
Roos SG Sablerolles et al, Ad26.COV2.S Immunogenicity and reactionogenicity of vaccine boosters after priming, New England Journal of Medicine (2022). DOI: 10.1056 / NEJMoa2116747

Provided by
Leiden University

Quote: The best way to strengthen the immune system after a single Janssen vaccination was obtained from https://medicalxpress.com/news/2022-01-boost-immune-janssen-vaccination- on January 24, 2022. Is to use the mRNA booster (January 24, 2022). mrna.html

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