Patients with breast cancer, pancreatic cancer, and certain other types of cancer survive longer when given anti-nausea drugs during surgery, according to a large study presented at the ANESTHESIOLOGY 2021 Annual Meeting. There is likely to be. Researchers found that three months after cancer surgery, the number of patients who did not receive dexamethasone died more than three times as much as those who received the drug.
Dexamethasone is given to patients after surgery and to prevent nausea and vomiting during chemotherapy. Researchers have found that dexamethasone is a patient with non-immunogenic cancers (cancers that do not provoke a strong immune response) such as sarcoma, breast cancer, uterine cancer, ovarian cancer, esophageal cancer, pancreatic cancer, and thyroid cancer. We have found that we can improve medium- to long-term outcomes. Bones and joints.
“Dexamethasone has positive and negative effects. It suppresses cancer growth, but Immune systemDr. Maximilian Schaefer, MD, senior author of the study and director of the Beth Israel Deaconess Medical Center and the Center for Anesthesia Research Excellence at Harvard Medical School in Boston, said.Immune system controls cancer Growth, positive Negative impact There is no benefit because the dexamethasone is balanced. Our study is the first large study to show that positive effects appear to predominate for a wide variety of cancers in which the immune system does not play a major role. “
Researchers found 74,058 patients who underwent surgery to remove non-immunogenic cancerous tumors at the Beth Israel Deaconess Medical Center from 2005 to 2020 and at Massachusetts General Hospital in Boston from 2007 to 2015. I analyzed the records of. Overall, 25,178 (34%) patients received dexamethasone during surgery. After 90 days, 209 patients (0.83%) who received dexamethasone died, compared with 1,543 patients (3.2%) who did not receive the drug.
Even after considering a variety of factors, including dexamethasone, which is often given to younger patients, patients who received this drug had a 21% reduction in their risk of dying within the first year after surgery. A second analysis found that dexamethasone was particularly beneficial to patients with cancer of the ovary, uterus, or cervix.
“Based on our data, physician anesthesiologists should be able to administer with greater confidence. Dexamethasone NS Patience “I’m undergoing surgery for non-immunogenic cancer,” said Dr. Schaefer. “It may not only relieve nausea, but may also improve survival.”
Courtesy of the American Society of Anesthesia
Quote: Anti-nausea drugs may help some cancer patients survive longer (October 9, 2021).
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