Insights from independent studies highlight why boosters are important to all adults, as widely anticipated decisions about COVID-19 vaccine boosters have been published by US agencies today.
Antibody levels after Pfizer-BioNTech COVID-19 vaccination vary by age and gender, but overall Antibody level According to, it fell sharply within 6 months Ongoing research It is headed by the Texas Biomedical Research Institute (Texas Biomed) and the University of Verona, Italy.
This study found that total antibody levels against SARS-CoV-2 differed between age groups and between males and females. Specifically, individuals under the age of 65 had more than double the antibody levels of individuals over the age of 65 for 6 months after vaccination. Antibody levels in females, especially those under the age of 65, were higher than in males. However, importantly, at 6 months, antibody levels decreased by more than 50% from the peak levels of all in the study.
“We know how vaccines can help keep people away from hospitals and prevent life-threatening illnesses, but antibody levels in everyone, regardless of age or gender, are dropping rapidly,” he said. Dr. Brandon Michael Henry, a physician scientist and postdoctoral researcher, said. At Texas Biomed, which co-led the research with an Italian collaborator. “Our study provides additional evidence that booster shots in all adults are important for maintaining antibody levels and that effective mounting can continue. Immune response Prevents COVID-19 infection and prevents death from COVID-19. “
The findings are based on a group of 787 healthcare workers in Verona, Italy, who received two doses of the Pfizer-BioNTech COVID-19 vaccine. Their age ranged from 21 to 75 years. Their antibody levels were measured before vaccination, after the second dose, and 1, 3 and 6 months after the second injection.Henry published his study at 9NS Year-round Vaccine Development Center in San Antonio Meeting on November 11th. This paper is Journal of Medical Biochemistry ((((Preprint here).
Henry and his collaborators Significant gender difference It has something to do with hormones.Higher testosterone in men naturally suppresses Immune systemOn the other hand, higher estrogen in females is known to amplify the immune response. Also, some genes that encode specific immune proteins are on the X chromosome, and females have two X chromosomes, which may help increase immune activity.
“Usually only one X chromosome is active and the other is almost inactive, but there is evidence that immune-related genes remain active on that redundant chromosome, helping to boost a woman’s immune response. “Henry says.
However, women, regardless of age, saw antibody levels drop by more than 50% from their peak by 6 months after vaccination.
Henry has also led a systematic review with similar results for age and gender. He and his colleagues have developed a way to standardize antibody-level research results by examining the rate of change in antibody levels. Overall 32 studies It covers more than 5,000 people.
“Through the pandemic, we’ve observed more older people and men suffering from the worst consequences of COVID-19,” says Henry. “These studies show that the immune response to SARS-CoV-2 is weak as a factor in this phenomenon.”
Henry emphasized that lowering antibody levels does not mean that the vaccine is ineffective. Different types of antibodies play different roles in the prevention of mild breakthrough infections and severe illnesses. Antibodies that help prevent severe illness appear to remain effective in most groups, even if they are present at low levels. Therefore, vaccination is important.However, these antibodies continue to decline over time, so booster doses help maintain adequate levels of these life-savings. antibody..
Friday, November 19, US Food and Drug Administration (FDA) Approved booster for all adults.. The Centers for Disease Control and Prevention (CDC) will soon issue a formal recommendation.Previously approved and recommended by the FDA and CDC Booster for a specific group of people.. Some states are already advancing to provide booster immunity to all adults 6 months after vaccination.
Gian Luca Salvagno et al, Total number of anti-SARS-CoV-2 antibodies measured 6 months after Pfizer-BioNTech COVID-19 vaccination in healthcare workers, SSRN e-journal (2021). DOI: 10.2139 / ssrn.3915349
Texas Biological Laboratories
Quote: Age, Gender, Declining COVID-19 Antibodies (November 19, 2021), https: //medicalxpress.com/news/2021-11-age-sex-waning-covid-antibodies.html to 2021 11 Obtained on the 19th of March.
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