Adding single type of bacteria to gut microbiome boosted anti-tumor immunity in mice

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Tertiary lymphatic structures, including helper T cells, B cells, and natural killer cells, create a suitable environment for immune cell maturation, indicating a high likelihood of successful cancer treatment. Credit: Abigail Overacre-Delgoffe

Bacteria common to the mouse gut flora can recharge the immune system to fight cancer cells in the colon, researchers at the University of Pittsburgh School of Medicine report today in the journal. Immunity..

In this study, the bacterium Helicobacter hepaticas enhances the adaptive immune response and promotes selective activation of helper T cells and antibody-producing B cells. Colon tumor Shortens and prolongs mouse survival.Pioneering research provides strong evidence to support utilization Gut microbiota Treat advanced colon cancer With tumors that are resistant to conventional drugs Immunotherapy..

“Modifying the gut flora does not have to rely on serendipity for therapeutic benefits,” said Pitt’s assistant professor of immunology and corresponding author, Dr. Timothy Hand. increase. “Instead of using a fecal transplant and hoping to be right Microbial composition, We are now in a much better position to develop effective drugs designed on the basis of the molecules produced by Beneficial bacteria.. ”

Colorectal cancer is a common and fatal disease that does not respond easily to immunotherapy because the tumor has the ability to modify its microenvironment and escape recognition by the tumor. Immune system.. To help these patients, oncologists have surgery, chemotherapy, Radiation therapy, All of these have a variety of debilitating side effects. Finding ways to make unresponsive cancers sensitive to immunotherapy can change the game.

Interestingly, some patients are better treated for colorectal cancer than others, and the gut flora may be the key to solving the mystery.

To test whether antitumor immunity can be enhanced by regulating the composition of the bacterial population in the colon, Pitt researchers are bacteria that inhabit the thick mucus of the intestinal lining and induce strong mucus. H. hepaticus was established in the intestine of mice with colon cancer. Immune response.

The addition of H. hepaticus significantly reduced the number and size of tumors and extended the lifespan of animals. Scientists say that helper T cells, B cells, and natural killer (NK) cells are more likely to be successfully treated by increasing infiltration of tumor sites and creating an environment suitable for immune cell maturation. Observed the formation of highly organized structures showing.

Researchers did not detect increased activation of cytotoxic T cells, which are often the target of immunotherapy, so they need to revisit colorectal cancer strategies to support helper T cells instead. Suggests that there is.

“Ignoring the effects of gut bacteria on successful cancer treatment seems like a major oversight,” said lead author Dr. Abigail Oberaker Delgoffe, Pitt’s Pediatrics and Damon Lanion Fellow. Said a postdoctoral fellow. “We need to think about everything a patient experiences every day that can lead to success or failure of treatment. Bacteria can no longer be ignored. They affect everything.”

Additional authors of this manuscript are Hannah Bumgarner, BS, Anthony Cillo, Ph.D., Ansen Burr, BS, Justin Tometich, BS, Amrita Bhattacharjee, Ph.D., Tullia Bruno, Ph.D. , And Dario Vignali, Ph. .D. , All in the pit.


Studies point to strategies for overcoming immunotherapy resistance in colorectal cancer


For more information:
Timothy W. Hand, a microbiota-specific T follicular helper cell, promotes tertiary lymphatic structure and antitumor immunity against colorectal cancer. Immunity (2021). DOI: 10.1016 / j.immuni.2021.11.003.. www.cell.com/immunity/fulltext… 1074-7613 (21) 00494-5

Quote: Addition of a single type of bacterium to the intestinal flora enhanced antitumor immunity in mice (December 2, 2021). .html

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Adding single type of bacteria to gut microbiome boosted anti-tumor immunity in mice Source link Adding single type of bacteria to gut microbiome boosted anti-tumor immunity in mice

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